Mitochondrial dysregulation, such as mitochondrial complex I deficiency, increased
oxidative stress, perturbation of mitochondrial dynamics and mitophagy, has long been …

Mitophagy, the selective degradation of mitochondria, is impaired in many
neurodegenerative diseases (NDs), resulting in an accumulation of dysfunctional …

Background Mitochondrial dysfunction and toxic protein aggregates have been shown to be
key features in the pathogenesis of neurodegenerative diseases, such as Parkinson's …

Abstract Parkinson's disease (PD), the second most common neurodegenerative disorder,
develops sporadically, likely through a combination of polygenic and environmental factors …

Background Alzheimer's disease (AD) is a prevalent neurodegenerative disorder causing
progressive dementia. Research suggests that microRNAs (miRNAs) could serve as …

Mitochondrial dysfunction is a common feature of C9orf72 amyotrophic lateral sclerosis/
frontotemporal dementia (ALS/FTD); however, it remains unclear whether this is a cause or …

Mitochondrial dysfunction such as excess production of reactive oxygen species (ROS) and
defective mitochondrial dynamics are common features of C9orf72 Amyotrophic Lateral …

Parkinson's disease (PD) is a debilitating neurodegenerative disorder characterized by the
progressive loss of dopaminergic neurons in the midbrain substantia nigra, resulting in …

Mutations in FBXO7 have been discovered to be associated with an atypical parkinsonism.
We report here a new homozygous missense mutation in a paediatric patient that causes an …

Parkinson's disease is a common neurodegenerative disease with movement disorders
associated with the intracytoplasmic deposition of aggregate proteins such as α-synuclein in …