The phosphate moiety (PO4-2) is the common structural motif of a wide range of natural
phosphorus-based biologically active compounds, which play important roles as metabolic …

Nucleoside triphosphates are moldable entities that can easily be functionalized at various
locations. The enzymatic polymerization of these modified triphosphate analogues …

Upon stimulation of membrane receptors, nicotinic acid adenine dinucleotide phosphate
(NAADP) is formed as second messenger within seconds and evokes Ca2+ signaling in …

We report on the synthesis and evaluation of three different nucleotide prodrug systems:(i)
nucleoside triphosphate analogues in which the γ-phosph (on) ate has two different …

The metabolic conversion of nucleoside analogues into their triphosphates often proceeds
insufficiently. Rate‐limitations can be at the mono‐, but also at the di‐and triphosphorylation …

Nucleoside triphosphate diphosphohydrolase1 (NTPDase1, CD39) inhibitors have potential
as novel drugs for the (immuno) therapy of cancer. They increase the extracellular …

We disclose a study on nucleoside triphosphate (NTP) analogues in which the γ-phosphate
is covalently modified by two different biodegradable masking units and d4T as nucleoside …

P‐Amidites can be used in iterative couplings to selectively give mixed PIII–PV anhydrides.
These intermediates can be oxidized followed by a rapid removal of the two terminal …

A procedure for the synthesis of nucleoside polyphosphates and their conjugates using
sulfonylimidazolium salts as key reagents is described. The procedure is rapid and high …

Oligophosphates play essential roles in biochemistry, and considerable research has been
directed toward the synthesis of both naturally occurring oligophosphates and their synthetic …