RNA-targeting CRISPR–Cas systems
SPB van Beljouw, J Sanders… - Nature Reviews …, 2023 - nature.com
CRISPR–Cas is a widespread adaptive immune system in bacteria and archaea that
protects against viral infection by targeting specific invading nucleic acid sequences …
protects against viral infection by targeting specific invading nucleic acid sequences …
A critical review: recent advancements in the use of CRISPR/Cas9 technology to enhance crops and alleviate global food crises
Genome editing (GE) has revolutionized the biological sciences by creating a novel
approach for manipulating the genomes of living organisms. Many tools have been …
approach for manipulating the genomes of living organisms. Many tools have been …
Discovery of diverse CRISPR-Cas systems and expansion of the genome engineering toolbox
CRISPR systems mediate adaptive immunity in bacteria and archaea through diverse
effector mechanisms and have been repurposed for versatile applications in therapeutics …
effector mechanisms and have been repurposed for versatile applications in therapeutics …
The tracrRNA in CRISPR biology and technologies
CRISPR-Cas adaptive immune systems in bacteria and archaea utilize short CRISPR RNAs
(crRNAs) to guide sequence-specific recognition and clearance of foreign genetic material …
(crRNAs) to guide sequence-specific recognition and clearance of foreign genetic material …
Metagenomic discovery of CRISPR-associated transposons
CRISPR-associated Tn7 transposons (CASTs) co-opt cas genes for RNA-guided
transposition. CASTs are exceedingly rare in genomic databases; recent surveys have …
transposition. CASTs are exceedingly rare in genomic databases; recent surveys have …
CRISPR-Cas systems are widespread accessory elements across bacterial and archaeal plasmids
R Pinilla-Redondo, J Russel… - Nucleic acids …, 2022 - academic.oup.com
Many prokaryotes encode CRISPR-Cas systems as immune protection against mobile
genetic elements (MGEs), yet a number of MGEs also harbor CRISPR-Cas components …
genetic elements (MGEs), yet a number of MGEs also harbor CRISPR-Cas components …
Applications of the versatile CRISPR‐Cas13 RNA targeting system
M Kordyś, R Sen, Z Warkocki - Wiley Interdisciplinary Reviews …, 2022 - Wiley Online Library
CRISPR‐Cas are adaptable natural prokaryotic defense systems that act against invading
viruses and plasmids. Among the six currently known major CRISPR‐Cas types, the type VI …
viruses and plasmids. Among the six currently known major CRISPR‐Cas types, the type VI …
Structure-guided discovery of ancestral CRISPR-Cas13 ribonucleases
The RNA-guided ribonuclease CRISPR-Cas13 enables adaptive immunity in bacteria and
programmable RNA manipulation in heterologous systems. Cas13s share limited sequence …
programmable RNA manipulation in heterologous systems. Cas13s share limited sequence …
Csx28 is a membrane pore that enhances CRISPR-Cas13b–dependent antiphage defense
AR VanderWal, JU Park, B Polevoda, JK Nicosia… - Science, 2023 - science.org
Type VI CRISPR-Cas systems use RNA-guided ribonuclease (RNase) Cas13 to defend
bacteria against viruses, and some of these systems encode putative membrane proteins …
bacteria against viruses, and some of these systems encode putative membrane proteins …
Creating memories: molecular mechanisms of CRISPR adaptation
H Lee, DG Sashital - Trends in biochemical sciences, 2022 - cell.com
Prokaryotes use clustered regularly interspaced short palindromic repeat (CRISPR) and
CRISPR-associated (Cas) proteins as an adaptive immune system. CRISPR-Cas systems …
CRISPR-associated (Cas) proteins as an adaptive immune system. CRISPR-Cas systems …