Contemporary sequencing studies often ignore the diploid nature of the human genome
because they do not routinely separate or'phase'maternally and paternally derived …

The particular combinations of alleles that define haplotypes along individual chromosomes
can be determined with increasing ease and accuracy by using current sequencing …

To investigate the consequences of hybridization between species, we studied three
replicate hybrid populations that formed naturally between two swordtail fish species …

Many existing cohorts contain a range of relatedness between genotyped individuals, either
by design or by chance. Haplotype estimation in such cohorts is a central step in many …

The DNA-binding protein PRDM9 has a critical role in specifying meiotic recombination
hotspots in mice and apes, but it appears to be absent from other vertebrate species …

Although the past decade has seen tremendous progress in our understanding of fine-scale
recombination, little is known about non-crossover (NCO) gene conversion. We report the …

Simulations of close relatives and identical by descent (IBD) segments are common in
genetic studies, yet most past efforts have utilized sex averaged genetic maps and ignored …

As the more recent next-generation sequencing (NGS) technologies provide longer read
sequences, the use of sequencing datasets for complete haplotype phasing is fast becoming …

We are in a time of great change in genetics that may dramatically impact human biology
and medicine. The completion of the human genome project, 1, 2 the development of low …

Haplotype reconstruction of distant genetic variants remains an unsolved problem due to the
short-read length of common sequencing data. Here, we introduce HapTree-X, a …