Atherosclerosis is orchestrated by complex interactions between vascular and inflammatory
cells. Traditionally, it has been considered to be an intimal inflammatory disease …

Adipose tissues are present at multiple locations in the body. Most blood vessels are
surrounded with adipose tissue which is referred to as perivascular adipose tissue (PVAT) …

In the elderly with atherosclerosis, hypertension and diabetes, vascular calcification and
ageing are ubiquitous. Melatonin (MT) has been demonstrated to impact the cardiovascular …

Mitochondria are indispensable organelles for maintaining cell energy metabolism, and also
are necessary to retain cell biological function by transmitting information as signal …

Recently, the emerging roles of adipocyte-derived extracellular vesicles (EVs) linking
obesity and its comorbidities have been recognized. In obese subjects, adipocytes are …

Rationale: For intravascular stent implantation to be successful, the processes of vascular
tissue repair and therapy are considered to be critical. However, the mechanisms underlying …

Alterations in the vascular smooth muscle cells (VSMC) phenotype play a critical role in the
pathogenesis of several cardiovascular diseases, including hypertension, atherosclerosis …

Type 2 diabetes mellitus (T2DM) is a complex multifactorial disease causing the
development of a large range of cardiovascular (CV) complications. Lifestyle changes and …

Diabetes mellitus (DM) is a chronic systemic disease with increasing prevalence globally.
An important aspect of diabetic pathogenesis is cellular crosstalk and information exchange …

Background Perivascular adipose tissue (PVAT) releases exosomes (EXOs) to regulate
vascular homeostasis. PVAT-derived EXOs reduce macrophage foam cell formation, but the …