[HTML][HTML] PPARgamma in metabolism, immunity, and cancer: unified and diverse mechanisms of action
M Hernandez-Quiles, MF Broekema… - Frontiers in …, 2021 - frontiersin.org
The proliferator-activated receptor γ (PPARγ), a member of the nuclear receptor superfamily,
is one of the most extensively studied ligand-inducible transcription factors. Since its …
is one of the most extensively studied ligand-inducible transcription factors. Since its …
Dimension reduction techniques for the integrative analysis of multi-omics data
State-of-the-art next-generation sequencing, transcriptomics, proteomics and other high-
throughput 'omics' technologies enable the efficient generation of large experimental data …
throughput 'omics' technologies enable the efficient generation of large experimental data …
Single-cell RNA sequencing highlights the role of inflammatory cancer-associated fibroblasts in bladder urothelial carcinoma
Z Chen, L Zhou, L Liu, Y Hou, M Xiong, Y Yang… - Nature …, 2020 - nature.com
Although substantial progress has been made in cancer biology and treatment, clinical
outcomes of bladder carcinoma (BC) patients are still not satisfactory. The tumor …
outcomes of bladder carcinoma (BC) patients are still not satisfactory. The tumor …
An integrated multi-omics analysis identifies prognostic molecular subtypes of non-muscle-invasive bladder cancer
SV Lindskrog, F Prip, P Lamy, A Taber… - Nature …, 2021 - nature.com
The molecular landscape in non-muscle-invasive bladder cancer (NMIBC) is characterized
by large biological heterogeneity with variable clinical outcomes. Here, we perform an …
by large biological heterogeneity with variable clinical outcomes. Here, we perform an …
[HTML][HTML] A consensus molecular classification of muscle-invasive bladder cancer
Background Muscle-invasive bladder cancer (MIBC) is a molecularly diverse disease with
heterogeneous clinical outcomes. Several molecular classifications have been proposed …
heterogeneous clinical outcomes. Several molecular classifications have been proposed …
[HTML][HTML] Commensal microbiota promote lung cancer development via γδ T cells
Lung cancer is closely associated with chronic inflammation, but the causes of inflammation
and the specific immune mediators have not been fully elucidated. The lung is a mucosal …
and the specific immune mediators have not been fully elucidated. The lung is a mucosal …
Comprehensive molecular characterization of muscle-invasive bladder cancer
We report a comprehensive analysis of 412 muscle-invasive bladder cancers characterized
by multiple TCGA analytical platforms. Fifty-eight genes were significantly mutated, and the …
by multiple TCGA analytical platforms. Fifty-eight genes were significantly mutated, and the …
Stem cell-associated heterogeneity in Glioblastoma results from intrinsic tumor plasticity shaped by the microenvironment
A Dirkse, A Golebiewska, T Buder, PV Nazarov… - Nature …, 2019 - nature.com
The identity and unique capacity of cancer stem cells (CSC) to drive tumor growth and
resistance have been challenged in brain tumors. Here we report that cells expressing CSC …
resistance have been challenged in brain tumors. Here we report that cells expressing CSC …
Keap1 loss promotes Kras-driven lung cancer and results in dependence on glutaminolysis
Treating KRAS-mutant lung adenocarcinoma (LUAD) remains a major challenge in cancer
treatment given the difficulties associated with directly inhibiting the KRAS oncoprotein. One …
treatment given the difficulties associated with directly inhibiting the KRAS oncoprotein. One …
Impact of molecular subtypes in muscle-invasive bladder cancer on predicting response and survival after neoadjuvant chemotherapy
Background An early report on the molecular subtyping of muscle-invasive bladder cancer
(MIBC) by gene expression suggested that response to neoadjuvant chemotherapy (NAC) …
(MIBC) by gene expression suggested that response to neoadjuvant chemotherapy (NAC) …