Redox reactions are intrinsically linked to energy metabolism. Therefore, redox processes
are indispensable for organismal physiology and life itself. The term reactive oxygen species …

The development of osteoarthritis (OA) correlates with a rise in the number of senescent
cells in joint tissues, and the senescence-associated secretory phenotype (SASP) has been …

Knee osteoarthritis (KOA) is one of the most common degenerative diseases, and its core
feature is the degeneration and damage of articular cartilage. The cartilage degeneration of …

Stabilization and activation of the p53 tumor suppressor are triggered in response to various
cellular stresses, including DNA damaging agents and elevated Reactive Oxygen Species …

Background: Impaired endothelium-dependent vasodilation is a hallmark of obesity-induced
hypertension. The recognition that Ca2+ signaling in endothelial cells promotes vasodilation …

Osteosarcoma (OS) is the most common primary bone tumor but current therapies still have
poor prognosis. Cold Atmospheric Plasma (CAP) and Plasma activated media (PAM) have …

The nuclear localized protein deacetylase, SIRT6, has been identified as a crucial regulator
of biological processes that drive aging. Among these processes, SIRT6 can promote …

Objective Cardiomyocyte senescence is an important contributor to cardiovascular diseases
and can be induced by stressors including DNA damage, oxidative stress, mitochondrial …

Neural stem/progenitor cells (NSPCs) contribute to the physiological cellular turnover of the
adult brain and make up its regenerative potential. It is thus essential to understand how …

The gut-brain axis mediates bidirectional signaling between the intestine and the nervous
system and is critical for organism-wide homeostasis. Here, we report the identification of a …