Heparan sulfate proteoglycans

S Sarrazin, WC Lamanna… - Cold Spring Harbor …, 2011 - cshperspectives.cshlp.org
Heparan sulfate proteoglycans are found at the cell surface and in the extracellular matrix,
where they interact with a plethora of ligands. Over the last decade, new insights have …

Generation of extracellular morphogen gradients: the case for diffusion

KS Stapornwongkul, JP Vincent - Nature Reviews Genetics, 2021 - nature.com
Cells within developing tissues rely on morphogens to assess positional information.
Passive diffusion is the most parsimonious transport model for long-range morphogen …

Screening cell–cell communication in spatial transcriptomics via collective optimal transport

Z Cang, Y Zhao, AA Almet, A Stabell, R Ramos… - Nature …, 2023 - nature.com
Spatial transcriptomic technologies and spatially annotated single-cell RNA sequencing
datasets provide unprecedented opportunities to dissect cell–cell communication (CCC) …

The wing imaginal disc

BK Tripathi, KD Irvine - Genetics, 2022 - academic.oup.com
The Drosophila wing imaginal disc is a tissue of undifferentiated cells that are precursors of
the wing and most of the notum of the adult fly. The wing disc first forms during …

[图书][B] Stochastic processes in cell biology

PC Bressloff - 2014 - Springer
One of the major challenges in modern biology is to understand how the molecular
components of a living cell operate in a highly noisy environment. What are the specific …

Heparan sulphate proteoglycans fine-tune mammalian physiology

JR Bishop, M Schuksz, JD Esko - Nature, 2007 - nature.com
Heparan sulphate proteoglycans reside on the plasma membrane of all animal cells studied
so far and are a major component of extracellular matrices. Studies of model organisms and …

Morphogen gradients: from generation to interpretation

KW Rogers, AF Schier - Annual review of cell and …, 2011 - annualreviews.org
Morphogens are long-range signaling molecules that pattern developing tissues in a
concentration-dependent manner. The graded activity of morphogens within tissues …

Genetic induction and mechanochemical propagation of a morphogenetic wave

A Bailles, C Collinet, JM Philippe, PF Lenne, E Munro… - Nature, 2019 - nature.com
Tissue morphogenesis arises from coordinated changes in cell shape driven by actomyosin
contractions. Patterns of gene expression regionalize cell behaviours by controlling …

Wnt signaling and stem cell control

R Nusse, C Fuerer, W Ching, K Harnish… - Cold Spring Harbor …, 2008 - symposium.cshlp.org
In many contexts, self-renewal and differentiation of stem cells are influenced by signals
from their environment, constituting a niche. It is postulated that stem cells compete for local …

Reconstitution of morphogen shuttling circuits

R Zhu, LA Santat, JS Markson, N Nandagopal… - Science …, 2023 - science.org
Developing tissues form spatial patterns by establishing concentration gradients of diffusible
signaling proteins called morphogens. The bone morphogenetic protein (BMP) morphogen …