Strategies for HIV-1 vaccines that induce broadly neutralizing antibodies
BF Haynes, K Wiehe, P Borrow, KO Saunders… - Nature Reviews …, 2023 - nature.com
After nearly four decades of research, a safe and effective HIV-1 vaccine remains elusive.
There are many reasons why the development of a potent and durable HIV-1 vaccine is …
There are many reasons why the development of a potent and durable HIV-1 vaccine is …
COVID-19 infection: implications for perioperative and critical care physicians
JR Greenland, MD Michelow, L Wang, MJ London - Anesthesiology, 2020 - pubs.asahq.org
Healthcare systems worldwide are responding to Coronavirus Disease 2019 (COVID-19),
an emerging infectious syndrome caused by the Severe Acute Respiratory Syndrome …
an emerging infectious syndrome caused by the Severe Acute Respiratory Syndrome …
[HTML][HTML] Restricted clonality and limited germinal center reentry characterize memory B cell reactivation by boosting
L Mesin, A Schiepers, J Ersching, A Barbulescu… - Cell, 2020 - cell.com
Repeated exposure to pathogens or their antigens triggers anamnestic antibody responses
that are higher in magnitude and affinity than the primary response. These involve …
that are higher in magnitude and affinity than the primary response. These involve …
[HTML][HTML] Germinal center B cell dynamics
L Mesin, J Ersching, GD Victora - Immunity, 2016 - cell.com
Germinal centers (GCs) are the site of antibody diversification and affinity maturation and as
such are vitally important for humoral immunity. The study of GC biology has undergone a …
such are vitally important for humoral immunity. The study of GC biology has undergone a …
Epitope-based vaccine design yields fusion peptide-directed antibodies that neutralize diverse strains of HIV-1
A central goal of HIV-1 vaccine research is the elicitation of antibodies capable of
neutralizing diverse primary isolates of HIV-1. Here we show that focusing the immune …
neutralizing diverse primary isolates of HIV-1. Here we show that focusing the immune …
Human circulating PD-1+ CXCR3− CXCR5+ memory Tfh cells are highly functional and correlate with broadly neutralizing HIV antibody responses
The vast majority of currently licensed human vaccines work on the basis of long-term
protective antibody responses. It is now conceivable that an antibody-dependent HIV …
protective antibody responses. It is now conceivable that an antibody-dependent HIV …
Developmental pathway for potent V1V2-directed HIV-neutralizing antibodies
Antibodies capable of neutralizing HIV-1 often target variable regions 1 and 2 (V1V2) of the
HIV-1 envelope, but the mechanism of their elicitation has been unclear. Here we define the …
HIV-1 envelope, but the mechanism of their elicitation has been unclear. Here we define the …
The promise and challenge of high-throughput sequencing of the antibody repertoire
G Georgiou, GC Ippolito, J Beausang, CE Busse… - Nature …, 2014 - nature.com
Efforts to determine the antibody repertoire encoded by B cells in the blood or lymphoid
organs using high-throughput DNA sequencing technologies have been advancing at an …
organs using high-throughput DNA sequencing technologies have been advancing at an …
Rational HIV immunogen design to target specific germline B cell receptors
Vaccine development to induce broadly neutralizing antibodies (bNAbs) against HIV-1 is a
global health priority. Potent VRC01-class bNAbs against the CD4 binding site of HIV gp120 …
global health priority. Potent VRC01-class bNAbs against the CD4 binding site of HIV gp120 …
Antibody responses to envelope glycoproteins in HIV-1 infection
DR Burton, JR Mascola - Nature immunology, 2015 - nature.com
Antibody responses to the HIV-1 envelope glycoproteins can be classified into three groups.
Binding but non-neutralizing responses are directed to epitopes that are expressed on …
Binding but non-neutralizing responses are directed to epitopes that are expressed on …