Next-generation sequencing (NGS) is present in all fields of life science, which has greatly
promoted the development of basic research while being gradually applied in clinical …

Recombination is a central biological process with implications for many areas in the life
sciences. Yet we are only beginning to appreciate variation in the recombination rate along …

Abstract We present Ginkgo (http://qb. cshl. edu/ginkgo), a user-friendly, open-source web
platform for the analysis of single-cell copy-number variations (CNVs). Ginkgo automatically …

The Sanger sequencing method produces relatively long DNA sequences of unmatched
quality and has been considered for long time as the gold standard for sequencing DNA …

Over the past decade, it has become nearly routine to sequence genomes of individual
microbial cells directly isolated from environmental samples ranging from deep-sea …

Hepatocellular carcinoma (HCC) is a cancer of substantial morphologic, genetic and
phenotypic diversity. Yet we do not understand the relationship between intratumor …

In this review we provide an overview of current challenges and advances in bacteriophage
research within the growing field of viromics. In particular, we discuss, from a human virome …

Single-cell RNA-seq (scRNA-seq) is a revolutionary technology that allows for the genomic
investigation of individual cells in a population, allowing for the discovery of unusual cells …

Designed to minimize chances of transferring genetically abnormal embryos,
preimplantation genetic diagnosis (PGD) involves in vitro fertilization (IVF), embryo biopsy …

With the development of high throughput sequencing and single-cell genomics
technologies, many uncultured bacterial communities have been dissected by combining …