Lyotropic liquid crystal engineering moving beyond binary compositional space–ordered nanostructured amphiphile self-assembly materials by design
Ordered amphiphile self-assembly materials with a tunable three-dimensional (3D)
nanostructure are of fundamental interest, and crucial for progressing several biological and …
nanostructure are of fundamental interest, and crucial for progressing several biological and …
Real‐Time pH‐Dependent Self‐Assembly of Ionisable Lipids from COVID‐19 Vaccines and In Situ Nucleic Acid Complexation
Ionisable amino‐lipid is a key component in lipid nanoparticles (LNPs), which plays a crucial
role in the encapsulation of RNA molecules, allowing efficient cellular uptake and then …
role in the encapsulation of RNA molecules, allowing efficient cellular uptake and then …
Correlating the structure and gene silencing activity of oligonucleotide-loaded lipid nanoparticles using small-angle X-ray scattering
With three FDA-approved products, lipid nanoparticles (LNPs) are under intensive
development for delivering wide-ranging nucleic acid therapeutics. A significant challenge …
development for delivering wide-ranging nucleic acid therapeutics. A significant challenge …
Acidification-Induced Structure Evolution of Lipid Nanoparticles Correlates with Their In Vitro Gene Transfections
Z Li, J Carter, L Santos, C Webster, CF van der Walle… - ACS …, 2023 - ACS Publications
The rational design of lipid nanoparticles (LNPs) for enhanced gene delivery remains
challenging because of incomplete knowledge of their formulation–structure relationship …
challenging because of incomplete knowledge of their formulation–structure relationship …
Advances in the design of ph-sensitive cubosome liquid crystalline nanocarriers for drug delivery applications
Nanostructure bicontinuous cubic phase self-assembled materials are receiving expanding
applications as biocompatible delivery systems in various therapeutic fields. The …
applications as biocompatible delivery systems in various therapeutic fields. The …
Brain-targeted co-delivery of therapeutic gene and peptide by multifunctional nanoparticles in Alzheimer's disease mice
Multifunctional nanocarriers are increasingly promising for disease treatment aimed to
regulate multiple pathological dysfunctions and overcome barriers in drug delivery. Here we …
regulate multiple pathological dysfunctions and overcome barriers in drug delivery. Here we …
Development of a microfluidic-based post-treatment process for size-controlled lipid nanoparticles and application to siRNA delivery
N Kimura, M Maeki, Y Sato, A Ishida… - … applied materials & …, 2020 - ACS Publications
Microfluidic methodologies for preparation of lipid nanoparticles (LNPs) based on an
organic solvent injection method enable precise size control of the LNPs. After preparation …
organic solvent injection method enable precise size control of the LNPs. After preparation …
A thermogelling supramolecular hydrogel with sponge-like morphology as a cytocompatible bioink
Biocompatible polymers that form thermoreversible supramolecular hydrogels have gained
great interest in biomaterials research and tissue engineering. When favorable rheological …
great interest in biomaterials research and tissue engineering. When favorable rheological …
Recent advances in the delivery and applications of nonviral CRISPR/Cas9 gene editing
The CRISPR (clustered regularly interspaced short palindromic repeats)/Cas9 genome
editing system has been a major technological breakthrough that has brought revolutionary …
editing system has been a major technological breakthrough that has brought revolutionary …