Investigations of long-term changes in brain structure and function that accompany chronic
exposure to drugs of abuse suggest that alterations in gene regulation contribute …

Drug addiction involves potentially life-long behavioral abnormalities that are caused in
vulnerable individuals by repeated exposure to a drug of abuse. The persistence of these …

ChIP-seq is increasingly being used for genome-wide profiling of histone modification
marks. It is of particular importance to compare ChIP-seq data of two different conditions …

The exploration of brain epigenomes, which consist of various types of DNA methylation and
covalent histone modifications, is providing new and unprecedented insights into the …

Major depressive disorder is a chronic, remitting syndrome involving widely distributed
circuits in the brain. Stable alterations in gene expression that contribute to structural and …

Alcohol abuse causes widespread changes in gene expression in human brain, some of
which contribute to alcohol dependence. Previous microarray studies identified individual …

Epigenetic mechanisms, which control chromatin structure and function, mediate changes in
gene expression that occur in response to diverse stimuli. Recent research has established …

Familial inheritance of drug abuse is composed of both genetic and environmental factors.
Additionally, epigenetic transgenerational inheritance may provide a means by which …

The hippocampus is a highly plastic brain region particularly susceptible to the effects of
environmental stress; it also shows dynamic changes in epigenetic marks in response to …

Psychiatric disorders are complex multifactorial illnesses involving chronic alterations in
neural circuit structure and function. While genetic factors are important in the etiology of …