Redox modulation of cellular signaling and metabolism through reversible oxidation of methionine sensors in calcium regulatory proteins
DJ Bigelow, TC Squier - Biochimica et Biophysica Acta (BBA)-Proteins and …, 2005 - Elsevier
Adaptive responses associated with environmental stressors are critical to cell survival.
Under conditions when cellular redox and antioxidant defenses are overwhelmed, the …
Under conditions when cellular redox and antioxidant defenses are overwhelmed, the …
Thioredoxin-dependent redox regulation of cellular signaling and stress response through reversible oxidation of methionines
DJ Bigelow, TC Squier - Molecular Biosystems, 2011 - pubs.rsc.org
The sensitive oxidations of sulfur containing amino acids (ie, cysteines and methionines)
commonly control protein function, and act as important signaling mechanisms to modify …
commonly control protein function, and act as important signaling mechanisms to modify …
[HTML][HTML] Plasma membrane Ca2+-ATPases: Targets of oxidative stress in brain aging and neurodegeneration
A Zaidi - World journal of biological chemistry, 2010 - ncbi.nlm.nih.gov
Abstract The plasma membrane Ca 2+-ATPase (PMCA) pumps play an important role in the
maintenance of precise levels of intracellular Ca 2+[Ca 2+] i, essential to the functioning of …
maintenance of precise levels of intracellular Ca 2+[Ca 2+] i, essential to the functioning of …
Calmodulin, conformational states, and calcium signaling. A single-molecule perspective
CK Johnson - Biochemistry, 2006 - ACS Publications
Single-molecule fluorescence measurements can provide a new perspective on the
conformations, dynamics, and interactions of proteins. Recent examples are described …
conformations, dynamics, and interactions of proteins. Recent examples are described …
The plant plasma membrane Ca2+ pump ACA8 contains overlapping as well as physically separated autoinhibitory and calmodulin-binding domains
L Bækgaard, L Luoni, MI De Michelis… - Journal of Biological …, 2006 - ASBMB
In plant Ca 2+ pumps belonging to the P 2B subfamily of P-type ATPases, the N-terminal
cytoplasmic domain is responsible for pump autoinhibition. Binding of calmodulin (CaM) to …
cytoplasmic domain is responsible for pump autoinhibition. Binding of calmodulin (CaM) to …
Importance of calcium
B Tandoğan, NN Ulusu - Turkish Journal of Medical Sciences, 2005 - journals.tubitak.gov.tr
Calcium is the most abundant mineral in the body. Calcium regulates many cellular
processes and has important structural roles in living organisms. Skeletal muscle structure …
processes and has important structural roles in living organisms. Skeletal muscle structure …
Conformational substates of calmodulin revealed by single-pair fluorescence resonance energy transfer: influence of solution conditions and oxidative modification
A calmodulin (CaM) mutant (T34, 110C-CaM) doubly labeled with fluorescence probes
AlexaFluor 488 and Texas Red in opposing domains (CaM-DA) has been used to examine …
AlexaFluor 488 and Texas Red in opposing domains (CaM-DA) has been used to examine …
Caloxins: a novel class of selective plasma membrane Ca2+ pump inhibitors obtained using biotechnology
MM Szewczyk, J Pande, AK Grover - Pflügers Archiv-European Journal of …, 2008 - Springer
Plasma membrane Ca 2+ pumps (PMCA) extrude cellular Ca 2+ with a high affinity and
hence play a major role in Ca 2+ homeostasis and signaling. Caloxins (selective …
hence play a major role in Ca 2+ homeostasis and signaling. Caloxins (selective …
Necrotic death of neurons following an excitotoxic insult is prevented by a peptide inhibitor of c‐jun N‐terminal kinase
PG Arthur, GP Matich, WW Pang, DY Yu… - Journal of …, 2007 - Wiley Online Library
Peptide inhibitors of c‐Jun N‐terminal kinase (JNK) have been shown to potently protect
against cerebral ischemia. The protective effect has been ascribed to prevention of …
against cerebral ischemia. The protective effect has been ascribed to prevention of …
Theoretically predicted structures of plasma membrane Ca2+-ATPase and their susceptibilities to oxidation
GH Lushington, A Zaidi, ML Michaelis - Journal of Molecular Graphics and …, 2005 - Elsevier
Oxidative damage to the plasma membrane Ca2+-ATPase (PMCA) appears to contribute to
the decreased clearance of intracellular Ca2+ in the neurons of aged brain, possibly …
the decreased clearance of intracellular Ca2+ in the neurons of aged brain, possibly …