Horizontal gene transfer among host-associated microbes

JM de Sousa, M Lourenço, I Gordo - Cell Host & Microbe, 2023 - cell.com
Horizontal gene transfer is an important evolutionary force, facilitating bacterial diversity. It is
thought to be pervasive in host-associated microbiomes, where bacterial densities are high …

Selfish, promiscuous and sometimes useful: how mobile genetic elements drive horizontal gene transfer in microbial populations

M Haudiquet, JM de Sousa… - … Transactions of the …, 2022 - royalsocietypublishing.org
Horizontal gene transfer (HGT) drives microbial adaptation but is often under the control of
mobile genetic elements (MGEs) whose interests are not necessarily aligned with those of …

Arbitrium communication controls phage lysogeny through non-lethal modulation of a host toxin–antitoxin defence system

P Guler, SO Bendori, T Borenstein, N Aframian… - Nature …, 2024 - nature.com
Temperate Bacillus phages often utilize arbitrium communication to control lysis/lysogeny
decisions, but the mechanisms by which this control is exerted remains largely unknown …

Dormant phages communicate via arbitrium to control exit from lysogeny

N Aframian, S Omer Bendori, S Kabel, P Guler… - Nature …, 2022 - nature.com
Temperate bacterial viruses (phages) can transition between lysis—replicating and killing
the host—and lysogeny, that is, existing as dormant prophages while keeping the host …

Mitigation of evolved bacterial resistance to phage therapy

C Torres-Barceló, PE Turner, A Buckling - Current Opinion in Virology, 2022 - Elsevier
The ease with which bacteria can evolve resistance to phages is a key consideration for
development of phage therapy. Here, we review recent work on the different evolutionary …

Structural and functional characterization of MrpR, the master repressor of the Bacillus subtilis prophage SPβ

K Kohm, E Jalomo-Khayrova, A Krüger… - Nucleic Acids …, 2023 - academic.oup.com
Prophages control their lifestyle to either be maintained within the host genome or enter the
lytic cycle. Bacillus subtilis contains the SPβ prophage whose lysogenic state depends on …

Bacterial MazF/MazE toxin-antitoxin suppresses lytic propagation of arbitrium-containing phages

Y Cui, X Su, C Wang, H Xu, D Hu, J Wang, K Pei… - Cell Reports, 2022 - cell.com
Temperate phages dynamically switch between lysis and lysogeny in their full life cycle.
Some Bacillus-infecting phages utilize a quorum-sensing-like intercellular communication …

Antagonistic interactions between phage and host factors control arbitrium lysis–lysogeny decision

S Zamora-Caballero, C Chmielowska… - Nature …, 2024 - nature.com
Phages can use a small-molecule communication arbitrium system to coordinate lysis–
lysogeny decisions, but the underlying mechanism remains unknown. Here we determined …

Unique relationships between phages and endospore-forming hosts

M Butala, A Dragoš - Trends in microbiology, 2023 - cell.com
As part of their survival strategy under harsh environmental conditions, endospore-forming
bacteria can trigger a sporulation developmental program. Although the regulatory cascades …

When bacteria are phage playgrounds: interactions between viruses, cells, and mobile genetic elements

E Pfeifer, JM Sousa, M Touchon, EPC Rocha - Current Opinion in …, 2022 - Elsevier
Highlights•Interactions between bacteria and phages are in a continuum between extreme
antagonism and occasional symbiosis, resulting in hypervarible defense and …