Cholinergic degeneration is significant in Lewy body disease, including Parkinson's
disease, dementia with Lewy bodies, and isolated REM sleep behaviour disorder. Extensive …

The limbic system describes a complex of brain structures central for memory, learning, as
well as goal directed and emotional behavior. In addition to pathological studies, recent …

Cognitive impairment (CI) is a characteristic non-motor feature of Parkinson disease (PD)
that poses a severe burden on the patients and caregivers, yet relatively little is known about …

Cognitive impairment is a well‐recognized and debilitating symptom of Parkinson's disease
(PD). Degradation in the cortical cholinergic system is thought to be a key contributor. Both …

The term free-water volume fraction (FWVF) refers to the signal fraction that could be found
as the cerebrospinal fluid of the brain, which has been demonstrated as a sensitive measure …

Most individuals with Parkinson's disease experience cognitive decline. Mounting evidence
suggests this is partially caused by cholinergic denervation due to α-synuclein pathology in …

INTRODUCTION Degeneration of cortical cholinergic projections from the nucleus basalis of
Meynert (NBM) is characteristic of dementia with Lewy bodies (DLB) and Alzheimer's …

Background The contribution of cholinergic degeneration to gait disturbance in Parkinson's
disease (PD) is increasingly recognized, yet its relationship with dopaminergic-resistant gait …

Purpose Employing free water (FW) imaging, a cutting-edge diffusion MRI technique, we
assessed neuroinflammation within deep gray matter (DGM) in small vessel disease (SVD) …

Background and purpose The specific pathophysiological mechanisms underlying postural
instability/gait difficulty (PIGD) and cognitive function in Parkinson's disease (PD) remain …