Antibiotic development challenges: the various mechanisms of action of antimicrobial peptides and of bacterial resistance

F Guilhelmelli, N Vilela, P Albuquerque… - Frontiers in …, 2013 - frontiersin.org
Antimicrobial peptides (AMPs) are natural antibiotics produced by various organisms such
as mammals, arthropods, plants, and bacteria. In addition to antimicrobial activity, AMPs can …

Lipoteichoic acid synthesis and function in gram-positive bacteria

MG Percy, A Gründling - Annual review of microbiology, 2014 - annualreviews.org
Lipoteichoic acid (LTA) is an important cell wall polymer found in gram-positive bacteria.
Although the exact role of LTA is unknown, mutants display significant growth and …

Immunity of the greater wax moth Galleria mellonella

I Wojda - Insect science, 2017 - Wiley Online Library
Investigation of insect immune mechanisms provides important information concerning
innate immunity, which in many aspects is conserved in animals. This is one of the reasons …

Resistance mechanisms to antimicrobial peptides in gram-positive bacteria

L Assoni, B Milani, MR Carvalho… - Frontiers in …, 2020 - frontiersin.org
With the alarming increase of infections caused by pathogenic multidrug-resistant bacteria
over the last decades, antimicrobial peptides (AMPs) have been investigated as a potential …

Bacteriocin-antimicrobial synergy: a medical and food perspective

H Mathur, D Field, MC Rea, PD Cotter, C Hill… - Frontiers in …, 2017 - frontiersin.org
The continuing emergence of multi-drug resistant pathogens has sparked an interest in
seeking alternative therapeutic options. Antimicrobial combinatorial therapy is one such …

Bacillus thuringiensis: an impotent pathogen?

B Raymond, PR Johnston, C Nielsen-LeRoux… - Trends in …, 2010 - cell.com
Bacillus thuringiensis (Bt) is an insecticidal bacterium that has successfully been used as a
biopesticide for many years. It is usually referred to as a soil-dwelling organism, as a result …

Bacterial strategies of resistance to antimicrobial peptides

HS Joo, CI Fu, M Otto - … of the Royal Society B: Biological …, 2016 - royalsocietypublishing.org
Antimicrobial peptides (AMPs) are a key component of the host's innate immune system,
targeting invasive and colonizing bacteria. For successful survival and colonization of the …

Antimicrobial activity of cationic antimicrobial peptides against gram-positives: current progress made in understanding the mode of action and the response of …

S Omardien, S Brul, SAJ Zaat - Frontiers in cell and developmental …, 2016 - frontiersin.org
Antimicrobial peptides (AMPs) have been proposed as a novel class of antimicrobials that
could aid the fight against antibiotic resistant bacteria. The mode of action of AMPs as acting …

Resistance to bacteriocins produced by Gram-positive bacteria

MCF Bastos, MLV Coelho, OCS Santos - Microbiology, 2015 - microbiologyresearch.org
Bacteriocins are prokaryotic proteins or peptides with antimicrobial activity. Most of them
exhibit a broad spectrum of activity, inhibiting micro-organisms belonging to different genera …

Response Mechanisms of Invertebrates to Bacillus thuringiensis and Its Pesticidal Proteins

D Pinos, A Andrés-Garrido, J Ferré… - Microbiology and …, 2021 - Am Soc Microbiol
Extensive use of chemical insecticides adversely affects both environment and human
health. One of the most popular biological pest control alternatives is bioinsecticides based …