Sensory hair cells are mechanoreceptors of the auditory and vestibular systems and are
crucial for hearing and balance. In adult mammals, auditory hair cells are unable to …

Vestibular sensation is essential for gaze stabilization, balance, and perception of gravity.
The vestibular receptors in mammals, Type I and Type II hair cells, are located in five small …

Whereas most epithelial tissues turn-over and regenerate after a traumatic lesion, this
restorative ability is diminished in the sensory epithelia of the inner ear; it is absent in the …

Background: Loss of peripheral vestibular function is associated with disease processes
such as vestibular neuronitis, aminoglycoside ototoxicity, and aging. Loss of vestibular hair …

Gentamicin is toxic to vestibular hair cells, but its effects on vestibular afferents have not
been defined. We treated anesthetized chinchillas with one injection of gentamicin (26.7 …

The regeneration of mechanoreceptive hair cells occurs throughout life in non-mammalian
vertebrates and allows them to recover from hearing and balance deficits that affect humans …

Objective To describe the mechanism and risk factors for the development of
aminoglycoside-induced vestibular injury and discuss their implications for therapeutic …

Although recent studies have provided evidence for hair cell regeneration in mammalian
inner ears, the mechanism underlying this regenerative process is still under debate. Here …

The degree of ototoxic drug sensitivity and hair cell repair was determined in the chinchilla
horizontal crista ampullaris after intraotic administration of gentamicin. Histological …

Clinically, gentamicin has been used extensively to treat the debilitating symptoms of
Mèniére's disease and is well known for its vestibulotoxic properties. Until recently, it was …