Desmosomes as signaling hubs in the regulation of cell behavior

L Müller, M Hatzfeld, R Keil - Frontiers in cell and developmental …, 2021 - frontiersin.org
Desmosomes are intercellular junctions, which preserve tissue integrity during homeostatic
and stress conditions. These functions rely on their unique structural properties, which …

Lipocalin 2 expression promotes tumor progression and therapy resistance by inhibiting ferroptosis in colorectal cancer

N Chaudhary, BS Choudhary, SG Shah… - … Journal of Cancer, 2021 - Wiley Online Library
Lipocalin 2 is a siderophore‐binding protein that regulates iron homeostasis. Lipocalin 2
expression is elevated in multiple tumor types; however, the mechanisms that drive tumor …

Tumor-on-a-chip platform to interrogate the role of macrophages in tumor progression

Y Bi, VS Shirure, R Liu, C Cunningham… - Integrative …, 2020 - academic.oup.com
Tumor-infiltrating leukocytes, in particular macrophages, play an important role in tumor
behavior and clinical outcome. The spectrum of macrophage subtypes ranges from …

Human primary epithelial cells acquire an epithelial-mesenchymal-transition phenotype during long-term infection by the oral opportunistic pathogen, Porphyromonas …

J Lee, JAS Roberts, KR Atanasova… - Frontiers in cellular …, 2017 - frontiersin.org
Porphyromonas gingivalis is a host-adapted oral pathogen associated with chronic
periodontitis that successfully survives and persists in the oral epithelium. Recent studies …

Biophysical survey of small-molecule β-catenin inhibitors: a cautionary tale

MA McCoy, D Spicer, N Wells… - Journal of Medicinal …, 2022 - ACS Publications
The canonical Wingless-related integration site signaling pathway plays a critical role in
human physiology, and its dysregulation can lead to an array of diseases. β-Catenin is a …

STIM-Orai channels and reactive oxygen species in the tumor microenvironment

J Frisch, A Angenendt, M Hoth, L Prates Roma, A Lis - Cancers, 2019 - mdpi.com
The tumor microenvironment (TME) is shaped by cancer and noncancerous cells, the
extracellular matrix, soluble factors, and blood vessels. Interactions between the cells …

Physiological and oncogenic roles of the PRL phosphatases

S Hardy, E Kostantin, T Hatzihristidis… - The FEBS …, 2018 - Wiley Online Library
The human Phosphatase of Regenerative Liver (PRL) family comprises three members
(PRL‐1,‐2,‐3; gene name PTP 4A1, PTP 4A2, PTP 4A3) that are highly expressed in a …

Identification of novel diagnostic biomarkers in prostate adenocarcinoma based on the stromal‐immune score and analysis of the WGCNA and ceRNA network

T Zhang, Y Wang, Y Dong, L Liu, Y Han… - Disease …, 2022 - Wiley Online Library
Prostate cancer is still a significant global health burden in the coming decade. Novel
biomarkers for detection and prognosis are needed to improve the survival of distant and …

DKK1 inhibits breast cancer cell migration and invasion through suppression of β-catenin/MMP7 signaling pathway

J Niu, XM Li, X Wang, C Liang, YD Zhang, HY Li… - Cancer cell …, 2019 - Springer
Background DKK1 has been reported to act as a tumor suppressor in breast cancer.
However, the mechanism of DKK1 inhibits breast cancer migration and invasion was still …

A Screening of Native (Poly) phenols and Gut‐Related Metabolites on 3D HCT116 Spheroids Reveals Gut Health Benefits of a Flavan‐3‐ol Metabolite

J Rubert, P Gatto, M Pancher… - Molecular Nutrition & …, 2022 - Wiley Online Library
Scope Epidemiological evidence suggests that a reduced risk of colorectal cancer (CRC) is
correlated with high consumption of fruits and vegetables, which are major sources of fiber …