Vascular endothelial growth factors (VEGFs) and their receptors (VEGFRs) are uniquely
required to balance the formation of new blood vessels with the maintenance and …

Cells migrate in multiple different ways depending on their environment, which includes the
extracellular matrix composition, interactions with other cells, and chemical stimuli. For all …

The resistance of cancer cells to therapy is responsible for the death of most patients with
cancer. Epithelial-to-mesenchymal transition (EMT) has been associated with resistance to …

Lung cancer is the leading cause of cancer death worldwide, and adenocarcinoma is its
most common histological subtype. Clinical and molecular evidence indicates that lung …

Since their discovery in the late eighties, the role of Rho GTPases in the regulation of cell
migration has been extensively studied and has mainly focused on the hallmark family …

Glutamine synthetase, encoded by the gene GLUL, is an enzyme that converts glutamate
and ammonia to glutamine. It is expressed by endothelial cells, but surprisingly shows …

Angiogenesis is known as one of the hallmarks in cancer which could play a key role in
providing oxygen and nutrients for tumor cells. It has been shown that tumor cannot grow …

Over the last few years, the ETS transcription factor ERG has emerged as a major regulator
of endothelial function. Multiple studies have shown that ERG plays a crucial role in …

Current antiangiogenic therapy is limited by its cytostatic nature and systemic side effects. To
address these limitations, we have unveiled the role of RhoJ, an endothelial-enriched Rho …

Background: Recently, the molecular classification of gastric cancer (GC) promotes the
advances of GC patients' precision therapy and prognosis prediction. According to the Asian …