AJ Ridley - Current opinion in cell biology, 2015 - Elsevier
Cells migrate in multiple different ways depending on their environment, which includes the extracellular matrix composition, interactions with other cells, and chemical stimuli. For all …
M Debaugnies, S Rodríguez-Acebes, J Blondeau… - Nature, 2023 - nature.com
The resistance of cancer cells to therapy is responsible for the death of most patients with cancer. Epithelial-to-mesenchymal transition (EMT) has been associated with resistance to …
SA Selamat, BS Chung, L Girard, W Zhang… - Genome …, 2012 - genome.cshlp.org
Lung cancer is the leading cause of cancer death worldwide, and adenocarcinoma is its most common histological subtype. Clinical and molecular evidence indicates that lung …
A Sadok, CJ Marshall - Small GTPases, 2014 - Taylor & Francis
Since their discovery in the late eighties, the role of Rho GTPases in the regulation of cell migration has been extensively studied and has mainly focused on the hallmark family …
Glutamine synthetase, encoded by the gene GLUL, is an enzyme that converts glutamate and ammonia to glutamine. It is expressed by endothelial cells, but surprisingly shows …
M Mashreghi, H Azarpara, MR Bazaz… - Journal of cellular …, 2018 - Wiley Online Library
Angiogenesis is known as one of the hallmarks in cancer which could play a key role in providing oxygen and nutrients for tumor cells. It has been shown that tumor cannot grow …
AV Shah, GM Birdsey, AM Randi - Vascular pharmacology, 2016 - Elsevier
Over the last few years, the ETS transcription factor ERG has emerged as a major regulator of endothelial function. Multiple studies have shown that ERG plays a crucial role in …
Current antiangiogenic therapy is limited by its cytostatic nature and systemic side effects. To address these limitations, we have unveiled the role of RhoJ, an endothelial-enriched Rho …
Z Ma, Q Sun, C Zhang, Q Zheng, Y Liu… - … Journal of Biological …, 2023 - ncbi.nlm.nih.gov
Background: Recently, the molecular classification of gastric cancer (GC) promotes the advances of GC patients' precision therapy and prognosis prediction. According to the Asian …