The JAK-STAT pathway at 30: Much learned, much more to do
The discovery of the Janus kinase (JAK)-signal transducer and activator of transcription
(STAT) pathway arose from investigations of how cells respond to interferons (IFNs) …
(STAT) pathway arose from investigations of how cells respond to interferons (IFNs) …
Mechanisms and consequences of Jak–STAT signaling in the immune system
AV Villarino, Y Kanno, JJ O'Shea - Nature immunology, 2017 - nature.com
Abstract Kinases of the Jak ('Janus kinase') family and transcription factors (TFs) of the STAT
('signal transducer and activator of transcription') family constitute a rapid membrane-to …
('signal transducer and activator of transcription') family constitute a rapid membrane-to …
Guidelines for the use of flow cytometry and cell sorting in immunological studies
A Cossarizza, HD Chang, A Radbruch… - European journal of …, 2019 - Wiley Online Library
These guidelines are a consensus work of a considerable number of members of the
immunology and flow cytometry community. They provide the theory and key practical …
immunology and flow cytometry community. They provide the theory and key practical …
The γc family of cytokines: basic biology to therapeutic ramifications
WJ Leonard, JX Lin, JJ O'Shea - Immunity, 2019 - cell.com
The common cytokine receptor γ chain, γ c, is a component of the receptors for interleukin-2
(IL-2), IL-4, IL-7, IL-9, IL-15, and IL-21. Mutation of the gene encoding γ c results in X-linked …
(IL-2), IL-4, IL-7, IL-9, IL-15, and IL-21. Mutation of the gene encoding γ c results in X-linked …
Interleukin-21, acting beyond the immunological synapse, independently controls T follicular helper and germinal center B cells
Germinal centers (GCs), transient structures within B cell follicles and central to affinity
maturation, require the coordinated behavior of T and B cells. IL-21, a pleiotropic T cell …
maturation, require the coordinated behavior of T and B cells. IL-21, a pleiotropic T cell …
Psoriasis: a STAT3-centric view
Signal Transducer and Activator of Transcription (STAT) 3 has recently emerged as a key
player in the development and pathogenesis of psoriasis and psoriatic-like inflammatory …
player in the development and pathogenesis of psoriasis and psoriatic-like inflammatory …
Glioblastoma induces the recruitment and differentiation of dendritic-like “hybrid” neutrophils from skull bone marrow
Tumor-associated neutrophil (TAN) effects on glioblastoma (GBM) biology remain under-
characterized. We show here that neutrophils with dendritic features—including …
characterized. We show here that neutrophils with dendritic features—including …
Dysregulated IFN-γ signals promote autoimmunity in STAT1 gain-of-function syndrome
AD Largent, K Lambert, K Chiang, N Shumlak… - Science Translational …, 2023 - science.org
Heterozygous signal transducer and activator of transcription 1 (STAT1) gain-of-function
(GOF) mutations promote a clinical syndrome of immune dysregulation characterized by …
(GOF) mutations promote a clinical syndrome of immune dysregulation characterized by …
STAT3 in the systemic inflammation of cancer cachexia
Weight loss is diagnostic of cachexia, a debilitating syndrome contributing mightily to
morbidity and mortality in cancer. Most research has probed mechanisms leading to muscle …
morbidity and mortality in cancer. Most research has probed mechanisms leading to muscle …
The common cytokine receptor γ chain family of cytokines
JX Lin, WJ Leonard - Cold Spring Harbor perspectives in …, 2018 - cshperspectives.cshlp.org
Interleukin (IL)-2, IL-4, IL-7, IL-9, IL-15, and IL-21 form a family of cytokines based on their
sharing the common cytokine receptor γ chain (γc), which was originally discovered as the …
sharing the common cytokine receptor γ chain (γc), which was originally discovered as the …