Natural products or nutraceuticals have been shown to elicit anti-aging, anti-cancer and
other health-enhancing effects. A key target of the effects of natural products may be the …

Numerous studies have shown that berberine and its derivatives demonstrate important anti-
tumor effects. However, the specific underlying mechanism remains unclear. Therefore …

Background Berberine (BBR), a compound extracted from a variety of medicinal herbs, has
been shown multiple pharmacological effects against cancer cells of different origins …

Metformin has been used as a glucose lowering drug for several centuries and is now a first-
line drug for type 2 diabetes mellitus (T2DM). Since the discovery that it activates AMP …

Cancer is the leading cause of death and one of the greatest barriers to increased life
expectancy worldwide. Currently, chemotherapy with synthetic drugs remains one of the …

Drug repurposing (or repositioning) is an emerging concept to use old drugs for new
treatment indications. Phytochemicals isolated from medicinal plants have been largely …

Background Numerous studies have explored the anti-tumor effect of berberine (BBR), but
little clinical evidence guides the use of BBR in cancer patients. Objectives Our aim was to …

Background Berberine, a plant-derived compound isolated from Coptis chinensis used in
traditional Chinese medicine, has been shown to possess anti-cancer properties. However …

Berberine, an isoquinoline alkaloid derived from Berberis vulgaris and plants of the
Ranunculaceae family, elicits a broad range of pharmacological effects, including anticancer …

Sorafenib resistance is one of the major factors affecting the prognosis of patients with
hepatocellular carcinoma (HCC). Increasing evidence has indicated that certain traditional …