Combating mosquito-borne diseases using genetic control technologies

GH Wang, S Gamez, RR Raban, JM Marshall… - Nature …, 2021 - nature.com
Mosquito-borne diseases, such as dengue and malaria, pose significant global health
burdens. Unfortunately, current control methods based on insecticides and environmental …

Symbiont-mediated cytoplasmic incompatibility: what have we learned in 50 years?

JD Shropshire, B Leigh, SR Bordenstein - Elife, 2020 - elifesciences.org
Cytoplasmic incompatibility (CI) is the most common symbiont-induced reproductive
manipulation. Specifically, symbiont-induced sperm modifications cause catastrophic mitotic …

Efficacy of Wolbachia-infected mosquito deployments for the control of dengue

A Utarini, C Indriani, RA Ahmad… - … England Journal of …, 2021 - Mass Medical Soc
Background Aedes aegypti mosquitoes infected with the w Mel strain of Wolbachia pipientis
are less susceptible than wild-type A. aegypti to dengue virus infection. Methods We …

Releasing incompatible males drives strong suppression across populations of wild and Wolbachia-carrying Aedes aegypti in Australia

NW Beebe, D Pagendam, BJ Trewin… - Proceedings of the …, 2021 - National Acad Sciences
Releasing sterile or incompatible male insects is a proven method of population
management in agricultural systems with the potential to revolutionize mosquito control …

[HTML][HTML] Reduced dengue incidence following deployments of Wolbachia-infected Aedes aegypti in Yogyakarta, Indonesia: a quasi-experimental trial using controlled …

C Indriani, W Tantowijoyo, E Rancès, B Andari… - Gates open …, 2020 - ncbi.nlm.nih.gov
Background: Ae. aegypti mosquitoes stably transfected with the intracellular bacterium
Wolbachia pipientis (wMel strain) have been deployed for biocontrol of dengue and related …

[HTML][HTML] A decade of stability for wMel Wolbachia in natural Aedes aegypti populations

PA Ross, KL Robinson, Q Yang, AG Callahan… - PLoS …, 2022 - journals.plos.org
Mosquitoes carrying Wolbachia endosymbionts are being released in many countries for
arbovirus control. The wMel strain of Wolbachia blocks Aedes-borne virus transmission and …

Bridging landscape ecology and urban science to respond to the rising threat of mosquito-borne diseases

PA Kache, M Santos-Vega, AM Stewart-Ibarra… - Nature Ecology & …, 2022 - nature.com
The prevalence of diseases borne by mosquitoes, particularly in the genus Aedes, is rising
worldwide. This has been attributed, in part, to the dramatic rates of contemporary …

Large-scale releases and establishment of wMel Wolbachia in Aedes aegypti mosquitoes throughout the Cities of Bello, Medellín and Itagüí, Colombia

ID Velez, A Uribe, J Barajas, S Uribe… - PLoS Neglected …, 2023 - journals.plos.org
Background The w Mel strain of Wolbachia has been successfully introduced into Aedes
aegypti mosquitoes and has been shown to reduce the transmission of dengue and other …

Differences in proteome perturbations caused by the Wolbachia strain wAu suggest multiple mechanisms of Wolbachia-mediated antiviral activity

SM Rainey, V Geoghegan, DA Lefteri, TH Ant… - Scientific Reports, 2023 - nature.com
Some strains of the inherited bacterium Wolbachia have been shown to be effective at
reducing the transmission of dengue virus (DENV) and other RNA viruses by Aedes aegypti …

Large-Scale Deployment and Establishment of Wolbachia Into the Aedes aegypti Population in Rio de Janeiro, Brazil

JSM Gesto, SB Pinto, FBS Dias, J Peixoto… - Frontiers in …, 2021 - frontiersin.org
Traditional methods of vector control have proven insufficient to reduce the alarming
incidence of dengue, Zika, and chikungunya in endemic countries. The bacterium symbiont …