[HTML][HTML] Single-cell multi-ome and immune profiles of the Inspiration4 crew reveal conserved, cell-type, and sex-specific responses to spaceflight
Spaceflight induces an immune response in astronauts. To better characterize this effect, we
generated single-cell, multi-ome, cell-free RNA (cfRNA), biochemical, and hematology data …
generated single-cell, multi-ome, cell-free RNA (cfRNA), biochemical, and hematology data …
[HTML][HTML] Collection of biospecimens from the inspiration4 mission establishes the standards for the space omics and medical atlas (SOMA)
Abstract The SpaceX Inspiration4 mission provided a unique opportunity to study the impact
of spaceflight on the human body. Biospecimen samples were collected from four crew …
of spaceflight on the human body. Biospecimen samples were collected from four crew …
The Space Omics and Medical Atlas (SOMA) and international astronaut biobank
Spaceflight induces molecular, cellular, and physiological shifts in astronauts and poses
myriad biomedical challenges to the human body, which are becoming increasingly relevant …
myriad biomedical challenges to the human body, which are becoming increasingly relevant …
[HTML][HTML] Direct RNA sequencing of astronaut blood reveals spaceflight-associated m6A increases and hematopoietic transcriptional responses
The advent of civilian spaceflight challenges scientists to precisely describe the effects of
spaceflight on human physiology, particularly at the molecular and cellular level. Newer …
spaceflight on human physiology, particularly at the molecular and cellular level. Newer …
[HTML][HTML] Transcriptomics analysis reveals molecular alterations underpinning spaceflight dermatology
Background Spaceflight poses a unique set of challenges to humans and the hostile
spaceflight environment can induce a wide range of increased health risks, including …
spaceflight environment can induce a wide range of increased health risks, including …
Genome and clonal hematopoiesis stability contrasts with immune, cfDNA, mitochondrial, and telomere length changes during short duration spaceflight
JS Garcia-Medina, K Sienkiewicz… - Precision Clinical …, 2024 - academic.oup.com
Abstract Background The Inspiration4 (I4) mission, the first all-civilian orbital flight mission,
investigated the physiological effects of short-duration spaceflight through a multi-omic …
investigated the physiological effects of short-duration spaceflight through a multi-omic …
[HTML][HTML] Aging and putative frailty biomarkers are altered by spaceflight
Human space exploration poses inherent risks to astronauts' health, leading to molecular
changes that can significantly impact their well-being. These alterations encompass …
changes that can significantly impact their well-being. These alterations encompass …
Molecular and physiologic changes in the SpaceX Inspiration4 civilian crew
Human spaceflight has historically been managed by government agencies, such as the
NASA Twins Study1, but new commercial spaceflight opportunities have opened spaceflight …
NASA Twins Study1, but new commercial spaceflight opportunities have opened spaceflight …