Multimodal single-cell profiling reveals neuronal vulnerability and pathological cell states in focal cortical dysplasia

IC Galvão, M Lemoine, LA Messias, PA Araújo… - iScience, 2024 - cell.com
Focal cortical dysplasia (FCD) is a neurodevelopmental condition characterized by
malformations of the cerebral cortex that often cause drug-resistant epilepsy. In this study …

Multimodal single-cell sequencing of the human cortex reveals neuronal vulnerability and activated glial cell states in focal cortical dysplasia

IC Galvao, M Lemoine, LA Messias, PA Araujo… - bioRxiv, 2024 - biorxiv.org
The role of the diverse brain cell types in focal cortical dysplasia (FCD) development and
epileptogenicity is not fully understood. Here, we performed multi-omics single-cell …