Recent strategies to develop innovative photosensitizers for enhanced photodynamic therapy

TC Pham, VN Nguyen, Y Choi, S Lee, J Yoon - Chemical reviews, 2021 - ACS Publications
This review presents a robust strategy to design photosensitizers (PSs) for various species.
Photodynamic therapy (PDT) is a photochemical-based treatment approach that involves the …

Antibiotic resistance and persistence—Implications for human health and treatment perspectives

M Huemer, S Mairpady Shambat, SD Brugger… - EMBO …, 2020 - embopress.org
Antimicrobial resistance (AMR) and persistence are associated with an elevated risk of
treatment failure and relapsing infections. They are thus important drivers of increased …

Rejuvenated photodynamic therapy for bacterial infections

Q Jia, Q Song, P Li, W Huang - Advanced healthcare materials, 2019 - Wiley Online Library
The emergence of multidrug resistant bacterial strains has hastened the exploration of
advanced microbicides and antibacterial techniques. Photodynamic antibacterial therapy …

Therapeutic potential of bacteriophage endolysins for infections caused by Gram-positive bacteria

H Liu, Z Hu, M Li, Y Yang, S Lu, X Rao - Journal of biomedical science, 2023 - Springer
Abstract Gram-positive (G+) bacterial infection is a great burden to both healthcare and
community medical resources. As a result of the increasing prevalence of multidrug-resistant …

The advantages and challenges of using endolysins in a clinical setting

E Murray, LA Draper, RP Ross, C Hill - Viruses, 2021 - mdpi.com
Antibiotic-resistant pathogens are increasingly more prevalent and problematic. Traditional
antibiotics are no longer a viable option for dealing with these multidrug-resistant microbes …

Phage-encoded endolysins

F Abdelrahman, M Easwaran, OI Daramola, S Ragab… - Antibiotics, 2021 - mdpi.com
Due to the global emergence of antibiotic resistance, there has been an increase in
research surrounding endolysins as an alternative therapeutic. Endolysins are phage …

The concept of an ideal antibiotic: implications for drug design

M Gajdács - Molecules, 2019 - mdpi.com
The emergence and spread of antibiotic-resistant pathogens is a major public health issue,
which requires global action of an intersectoral nature. Multidrug-resistant (MDR) pathogens …

Livestock-associated methicillin-resistant Staphylococcus aureus (LA-MRSA) prevalence in humans in close contact with animals and measures to reduce on-farm …

D Crespo-Piazuelo, PG Lawlor - Irish veterinary journal, 2021 - Springer
Since the 1940s, Staphylococcus aureus has adapted to the use of different antimicrobials to
treat infections. Although S. aureus can act as a commensal bacterium, some strains are …

Endolysin, a promising solution against antimicrobial resistance

M Rahman, W Wang, Q Sun, JA Shah, C Li, Y Sun, Y Li… - Antibiotics, 2021 - mdpi.com
Antimicrobial resistance (AMR) is a global crisis for human public health which threatens the
effective prevention and control of ever-increasing infectious diseases. The advent of …

Non-traditional antibacterial therapeutic options and challenges

U Theuretzbacher, LJV Piddock - Cell host & microbe, 2019 - cell.com
The global challenges presented by drug-resistant bacterial infections have stimulated much
activity in finding new treatments. This review summarizes the progress and setbacks of non …