The cancer stem cell (CSC) hypothesis has captured the attention of many scientists. It is
believed that elimination of CSCs could possibly eradicate the whole cancer. CSC surface …

Stem cells represent natural units of embryonic development and tissue regeneration.
Embryonic stem (ES) cells, in particular, possess a nearly unlimited self-renewal capacity …

Early-stage mammalian embryos develop in a low O2 environment (hypoxia). hES cells,
however, are generally cultured under an atmosphere of 21% O2 (normoxia), under which …

We compared gene expression profiles of mouse and human ES cells by
immunocytochemistry, RT-PCR, and membrane-based focused cDNA array analysis …

Human pluripotent stem cells (PSCs) exist in naive and primed states and provide important
models to investigate the earliest stages of human development. Naive cells can be …

Human ESCs (hESCs) respond to signals that determine their pluripotency, proliferation,
survival, and differentiation status. In this report, we demonstrate that phosphatidylinositol 3 …

Understanding the molecular mechanism by which pluripotency is maintained in human
embryonic stem cells (hESC) is important for the development of improved methods to …

Human embryonic stem cells have been defined as self-renewing cells that can give rise to
many types of cells of the body. How and whether these cells can be manipulated to replace …

Previous studies have shown that prolonged propagation of undifferentiated human
embryonic stem cells (hESCs) requires conditioned medium from mouse embryonic feeders …

The greatest therapeutic promise of human embryonic stem cells (hESC) is to generate
specialized cells to replace damaged tissue in patients suffering from various degenerative …