Breast cancer is the most common invasive cancer to affect women both in North America
and in the world. It is the second highest cause of cancer death in women after lung cancer …

Breast cancer (BC) is the most common cancer of women all over the world. BRCA1 and
BRCA2 gene mutations comprise the most important genetic susceptibility of BC. Except for …

Objectives: Triple-negative breast cancer is regarded as an aggressive disease that affects a
young patient population and for which effective targeted therapy is not yet available …

Breast cancer is a heterogeneous disease, manifesting in a broad differentiation in
phenotypes and morphologic profiles, resulting in variable clinical behavior. Between 10 …

Triple-negative breast cancer (TNBC) represents a subgroup of breast cancers (BC)
associated with the most aggressive clinical behavior. No targeted therapy is currently …

Natural products have represented attractive alternatives for disease prevention and
treatment over the course of human history and have contributed to the development of …

Inherited mutations in the tumor suppressor genes BRCA1 and BRCA2 cause increased risk
of developing various cancers, especially breast and ovarian cancers. Tumors that develop …

The tumor genome is commonly aberrant as a consequence of mutagenic insult and
incomplete DNA repair. DNA repair as a therapeutic target has recently received …

Scope Reduced expression of tumor suppressor genes (TSG) increases the susceptibility to
breast cancer. However, only a small percentage of breast tumors is related to family history …

Breast cancer (BC) is a heterogeneous disease in an urgent need for developing novel
research, classification, and therapy approaches. Breast cancer 1 (BRCA1) and breast …