The multifaceted roles of copper in cancer: A trace metal element with dysregulated metabolism, but also a target or a bullet for therapy

P Lelièvre, L Sancey, JL Coll, A Deniaud, B Busser - Cancers, 2020 - mdpi.com
Simple Summary Copper is an essential element for human life. However, its redox activity
can be detrimental for the cell that developed highly coordinated pathways to chelate and …

[HTML][HTML] Von Willebrand factor and cancer; metastasis and coagulopathies

S Patmore, SPS Dhami, JM O'Sullivan - Journal of Thrombosis and …, 2020 - Elsevier
Von Willebrand factor (VWF) is a multimeric procoagulant plasma glycoprotein that mediates
platelet adhesion along the endothelium. In addition to its role maintaining normal …

ABO blood group type and risk of venous thromboembolism in patients with cancer

C Englisch, F Moik, S Nopp, M Raderer… - Blood …, 2022 - ashpublications.org
Venous thromboembolism (VTE) is common in patients with cancer. Although in the general
population blood type non-O is associated with increased VTE risk, the impact of ABO blood …

Pathophysiology 1. Mechanisms of thrombosis in cancer patients

A Falanga, F Schieppati, L Russo - Thrombosis and hemostasis in cancer, 2019 - Springer
Thrombosis is a major cause of morbidity and mortality in cancer patients. The pathogenesis
of blood coagulation activation in oncological patients is complex and involves both clinical …

High factor VIII levels independently predict venous thromboembolism in cancer patients: the cancer and thrombosis study

R Vormittag, R Simanek, C Ay, D Dunkler… - … , and vascular biology, 2009 - Am Heart Assoc
Objective—Patients with cancer are at an increased risk for venous thromboembolism (VTE).
Clotting factor VIII activity (FVIII) has been established as risk factor of primary and recurrent …

Elevated plasma D-dimer levels correlate with long term survival of gastric cancer patients

L Liu, X Zhang, B Yan, Q Gu, X Zhang, J Jiao, D Sun… - PloS one, 2014 - journals.plos.org
Background Increasing evidence indicated plasma D-dimer could be regarded as a marker
in cancers, however, its role in gastric cancer is still largely unknown. Methods Plasma D …

Increased coagulation activity and genetic polymorphisms in the F5, F10 and EPCRgenes are associated with breast cancer: a case-control study

M Tinholt, MK Viken, AE Dahm, HKM Vollan… - Bmc Cancer, 2014 - Springer
Background The procoagulant state in cancer increases the thrombotic risk, but also
supports tumor progression. To investigate the molecular mechanisms controlling cancer …

Prognostic influence of pre-operative C-reactive protein in node-negative breast cancer patients

I Sicking, K Edlund, E Wesbuer, V Weyer, MJ Battista… - PloS one, 2014 - journals.plos.org
The importance of inflammation is increasingly noticed in cancer. The aim of this study was
to analyze the prognostic influence of pre-operative serum C-reactive protein (CRP) in a …

The breast cancer coagulome in the tumor microenvironment and its role in prognosis and treatment response to chemotherapy

M Tinholt, X Tekpli, LA Torland, A Tahiri… - Journal of Thrombosis …, 2024 - Elsevier
Background The procoagulant phenotype in cancer is linked to thrombosis, cancer
progression, and immune response. A novel treatment that reduces the risk of both …

Clinical significance of plasma D-dimer in ovarian cancer: a meta-analysis

J Wu, Z Fu, G Liu, P Xu, J Xu, X Jia - Medicine, 2017 - journals.lww.com
Background: D-dimer has been widely used for the diagnosis and prognosis of ovarian
cancer, but there is still controversy on its prediction value of ovarian cancer. Objectives: To …