Mesenchymal stromal cells: from discovery to manufacturing and commercialization

A Mizukami, K Swiech - Stem cells international, 2018 - Wiley Online Library
Over the last decades, mesenchymal stromal cells (MSC) have been the focus of intense
research by academia and industry due to their unique features. MSC can be easily isolated …

Large‐scale expansion of human mesenchymal stem cells

MNFB Hassan, MD Yazid, MHM Yunus… - Stem Cells …, 2020 - Wiley Online Library
Mesenchymal stem cells (MSCs) are multipotent stem cells with strong immunosuppressive
property that renders them an attractive source of cells for cell therapy. MSCs have been …

Influence of microenvironment on mesenchymal stem cell therapeutic potency: from planar culture to microcarriers

AC Tsai, R Jeske, X Chen, X Yuan, Y Li - Frontiers in bioengineering …, 2020 - frontiersin.org
Human mesenchymal stem cells (hMSCs) are a promising candidate in cell therapy as they
exhibit multilineage differentiation, homing to the site of injury, and secretion of trophic …

Cell surface markers for mesenchymal stem cells related to the skeletal system: A scoping review

LN Fonseca, S Bolívar-Moná, T Agudelo, LD Beltrán… - Heliyon, 2023 - cell.com
Multipotent mesenchymal stromal cells (MSCs) have been described as bone marrow
stromal cells, which can form cartilage, bone or hematopoietic supportive stroma. In 2006 …

Cells as advanced therapeutics: State-of-the-art, challenges, and opportunities in large scale biomanufacturing of high-quality cells for adoptive immunotherapies

NJ Dwarshuis, K Parratt, A Santiago-Miranda… - Advanced drug delivery …, 2017 - Elsevier
Therapeutic cells hold tremendous promise in treating currently incurable, chronic diseases
since they perform multiple, integrated, complex functions in vivo compared to traditional …

From “bench to bedside”: current advancement on large-scale production of mesenchymal stem cells

V Bunpetch, H Wu, S Zhang… - Stem cells and …, 2017 - liebertpub.com
Mesenchymal stem cells (MSCs) are the primary cell source in cell therapy and regenerative
medicine due to its extraordinary self-renewing capacity and multilineage differentiation …

Regulation of mesenchymal stem cell 3D microenvironment: From macro to microfluidic bioreactors

S Sart, SN Agathos, Y Li, T Ma - Biotechnology journal, 2016 - Wiley Online Library
Human mesenchymal stem cells (hMSCs) have emerged as an important cell type in cell
therapy and tissue engineering. In these applications, maintaining the therapeutic properties …

Aggregation kinetics of human mesenchymal stem cells under wave motion

AC Tsai, Y Liu, X Yuan, R Chella, T Ma - Biotechnology journal, 2017 - Wiley Online Library
Human mesenchymal stem cells (hMSCs) are primary candidates in cell therapy and
regenerative medicine but preserving their therapeutic potency following culture expansion …

Bioprocessing of human mesenchymal stem cells: From planar culture to microcarrier-based bioreactors

AC Tsai, CA Pacak - Bioengineering, 2021 - mdpi.com
Human mesenchymal stem cells (hMSCs) have demonstrated great potential to be used as
therapies for many types of diseases. Due to their immunoprivileged status, allogeneic …

Chitosan scaffolds as microcarriers for dynamic culture of human neural stem cells

Y Ando, FC Chang, M James, Y Zhou, M Zhang - Pharmaceutics, 2023 - mdpi.com
Human neural stem cells (hNSCs) possess remarkable potential for regenerative medicine
in the treatment of presently incurable diseases. However, a key challenge lies in producing …