Genomic instability in human cancer: Molecular insights and opportunities for therapeutic attack and prevention through diet and nutrition

LR Ferguson, H Chen, AR Collins, M Connell… - Seminars in cancer …, 2015 - Elsevier
Genomic instability can initiate cancer, augment progression, and influence the overall
prognosis of the affected patient. Genomic instability arises from many different pathways …

Cancer prevention by targeting angiogenesis

A Albini, F Tosetti, VW Li, DM Noonan… - Nature reviews Clinical …, 2012 - nature.com
Healthy individuals can harbour microscopic tumours and dysplastic foci in different organs
in an undetectable and asymptomatic state for many years. These lesions do not progress in …

Cancer prevention with promising natural products: mechanisms of action and molecular targets

P Pratheeshkumar, C Sreekala, Z Zhang… - Anti-Cancer Agents …, 2012 - ingentaconnect.com
Cancer is the second leading cause of death worldwide. There is greater need for more
effective and less toxic therapeutic and preventive strategies. Natural products are becoming …

Structure-based classification and anti-cancer effects of plant metabolites

SA Shin, SY Moon, WY Kim, SM Paek, HH Park… - International journal of …, 2018 - mdpi.com
A variety of malignant cancers affect the global human population. Although a wide variety of
approaches to cancer treatment have been studied and used clinically (surgery …

Health promoting effects of brassica‐derived phytochemicals: from chemopreventive and anti‐inflammatory activities to epigenetic regulation

AE Wagner, AM Terschluesen… - Oxidative medicine and …, 2013 - Wiley Online Library
A high intake of brassica vegetables may be associated with a decreased chronic disease
risk. Health promoting effects of Brassicaceae have been partly attributed to glucosinolates …

First evidence that γ-tocotrienol inhibits the growth of human gastric cancer and chemosensitizes it to capecitabine in a xenograft mouse model through the modulation …

KA Manu, MK Shanmugam, L Ramachandran, F Li… - Clinical Cancer …, 2012 - AACR
Purpose: Because of poor prognosis and development of resistance against
chemotherapeutic drugs, the existing treatment modalities for gastric cancer are ineffective …

Isothiocyanates: a class of bioactive metabolites with chemopreventive potential

G Kumar, HS Tuli, S Mittal, JK Shandilya, A Tiwari… - Tumor Biology, 2015 - Springer
In recent years, growing interest has been focused on the field of chemoprevention using
natural therapies. The reason to turn toward “natural” remedies is associated with diverse …

Mechanism of action of phenethylisothiocyanate and other reactive oxygen species-inducing anticancer agents

I Jutooru, AS Guthrie, G Chadalapaka… - … and cellular biology, 2014 - Taylor & Francis
Reactive oxygen species (ROS)-inducing anticancer agents such as
phenethylisothiocyanate (PEITC) activate stress pathways for killing cancer cells. Here we …

Cruciferous vegetable consumption and gastric cancer risk: A meta‐analysis of epidemiological studies

QJ Wu, Y Yang, J Wang, LH Han, YB Xiang - Cancer science, 2013 - Wiley Online Library
The relationship between consumption of cruciferous vegetables (CV) and risk of gastric
cancer has been investigated by many studies, but remains controversial. We carried out a …

Modulation of TLR/NF-κB/NLRP signaling by bioactive phytocompounds: A promising strategy to augment cancer chemotherapy and immunotherapy

S Fakhri, SZ Moradi, A Yarmohammadi… - Frontiers in …, 2022 - frontiersin.org
Background Tumors often progress to a more aggressive phenotype to resist drugs. Multiple
dysregulated pathways are behind this tumor behavior which is known as cancer …