Obesity has been linked to the increased risk and aggressiveness of many types of
carcinoma. A state of chronic inflammation in adipose tissue (AT), resulting in genotoxic …

Development of novel and effective therapeutics for treating various cancers is probably the
most congested and challenging enterprise of pharmaceutical companies. Diverse drugs …

Oncogene-induced metabolic reprogramming is a hallmark of pancreatic cancer (PDAC), yet
the metabolic drivers of metastasis are unclear. In PDAC, obesity and excess fatty acids …

Background Emerging evidence supports the pivotal roles of adipocytes in breast cancer
progression. Tumour induced beige/brown adipose tissue differentiation contributes to the …

Emerging evidence shows that palmitic acid (PA), a common fatty acid in the human diet,
serves as a signaling molecule regulating the progression and development of many …

The way cancer cells utilize nutrients to support their growth and proliferation is determined
by cancer cell-intrinsic and cancer cell-extrinsic factors, including interactions with the …

Obesity is a leading contributing factor to cancer development worldwide. Epidemiological
evidence suggests that diet affects cancer risk and also substantially alters therapeutic …

Obesity is known to have important roles in driving prostate cancer aggressiveness and
increased mortality. Multiple mechanisms have been postulated for these clinical …

Pancreatic ductal adenocarcinoma (PDAC) is projected to become the second deadliest
cancer by 2030, and the overall 5-year survival rate is currently less than 7%. Cancer cells …

Epidemiologic data has linked obesity to a higher risk of pancreatic cancer, but the
underlying mechanisms are poorly understood. To allow for detailed mechanistic studies in …