Since the initial detection of TH2 cytokines in asthmatic airways, our understanding of the
complexity of T-cell subtypes and flexibility and of the potential role of airway structural cells …

Cells of the innate immune system interact with pathogens via conserved pattern-recognition
receptors, whereas cells of the adaptive immune system recognize pathogens through …

Associated with the CD1d protein, KRN 7000, a potent synthetic α-galactosylceramide, is
known to activate the invariant NKT immune cells. This stimulation then leads to the …

BACKGROUND: Asthma is defined as a chronic inflammatory disease of the airways;
however, the underlying physiologic and immunologic processes are not fully understood …

Natural killer T (NKT) cells are a subset of T lymphocytes that share surface markers and
functional characteristics with both conventional T lymphocytes and natural killer cells. Most …

Regulation and induction of anergy in NKT cells of the liver can inhibit autoimmune and
antitumor responses by mechanisms that are poorly understood. We investigated the effects …

Asthma is an allergic airways disease (AAD) caused by dysregulated immune responses
and characterized by eosinophilic inflammation, mucus hypersecretion, and airway …

The plasma membrane of cells contains a diverse array of lipids that provide important
structural and biological features. Glycolipids are typically a minor component of the cell …

Cytotoxic lymphocytes encompass natural killer lymphocytes (cells) and cytotoxic T cells that
include CD8+ T cells, natural killer (NK) T cells, γ, δ (γδ)‐T cells and human CD4+ CD28− T …

T helper 2 (Th2) cells play crucial roles in the development of allergic asthma, while various
distinct cell populations also contribute to the pathogenesis of the disease. Invariant natural …