Iron-Mediated Regulation in Adipose Tissue: A Comprehensive Review of Metabolism and Physiological Effects

X Yang, X Wang, Z Yang, H Lu - Current Obesity Reports, 2025 - Springer
Abstract Purpose of Review Review the latest data regarding the intersection of adipose
tissue (AT) and iron to meet the needs of AT metabolism and the progression of related …

Research progress on relationship between iron overload and lower limb arterial disease in type 2 diabetes mellitus

Z Wang, S Fang, S Ding, Q Tan… - … , Metabolic Syndrome and …, 2022 - Taylor & Francis
Iron is one of the most important trace elements in life activities. It participates in a variety of
important physiological processes in the body through oxidation-reduction reaction. A large …

Machine learning models identify ferroptosis-related genes as potential diagnostic biomarkers for Alzheimer's disease

Y Deng, Y Feng, Z Lv, J He, X Chen, C Wang… - Frontiers in Aging …, 2022 - frontiersin.org
Alzheimer's disease (AD) is a complex, and multifactorial neurodegenerative disease.
Previous studies have revealed that oxidative stress, synaptic toxicity, autophagy, and …

High Iron Exposure from the Fetal Stage to Adulthood in Mice Alters Lipid Metabolism

M Kim, Y Kim, S Min, SM Lee - Nutrients, 2022 - mdpi.com
Iron supplementation is recommended during pregnancy and fetal growth. However, excess
iron exposure may increase the risk of abnormal fetal development. We investigated the …

Adiponectin reduces glomerular endothelial glycocalyx disruption and restores glomerular barrier function in a mouse model of type 2 diabetes

S Fawaz, A Martin Alonso, Y Qiu, R Ramnath… - Diabetes, 2024 - Am Diabetes Assoc
Adiponectin has vascular anti-inflammatory and protective effects. Although adiponectin
protects against the development of albuminuria, historically, the focus has been on …

Associations of dietary total, heme, non-heme iron intake with diabetes, CVD, and all-cause mortality in men and women with diabetes

Y Jin, Y Huang, T Zhang, Q Sun, Y Zhang, P Zhang… - Heliyon, 2024 - cell.com
Background Iron metabolism disorders significantly increase the risk of diabetes and its
related complications by inducing oxidative stress, inflammation, insulin resistance, and …

Multiple metal exposure and metabolic syndrome in elderly individuals: A case-control study in an active mining district, Northwest China

S Guo, L Hua, W Liu, H Liu, Q Chen, Y Li, X Li, L Zhao… - Chemosphere, 2023 - Elsevier
The prevalence of metabolic syndrome (MetS) is increasing at an alarming rate worldwide,
particularly among elderly individuals. Exposure to various metals has been linked to the …

[HTML][HTML] Cardioprotective Effects of Adiponectin-Stimulated Autophagy

E Tam, M Ouimet, G Sweeney - Journal of Lipid and Atherosclerosis, 2025 - e-jla.org
Cardiovascular diseases (CVDs), including heart failure, pose a significant economic and
health burden worldwide. Current treatment strategies for heart failure are greatly limited, in …

[HTML][HTML] Importance of autophagy in mediating cellular responses to iron overload in cardiomyocytes

E Tam, C Reno, K Nguyen, S Cho… - Reviews in …, 2022 - imrpress.com
Both iron overload and deficiency can promote development of cardiomyopathy. Advances
in our knowledge from recent research have indicated numerous potential cellular …

DDAH1/ADMA regulates adiponectin resistance in cerebral ischemia via the ROS/FOXO1/APR1 pathway

Y Zhao, M Zhang, Y Dou, K Du, X Liu… - Oxidative medicine and …, 2022 - Wiley Online Library
Dimethylarginine dimethylaminohydrolase 1 (DDAH1) protects against cerebral ischemia
injury via regulating the level of asymmetric dimethylarginine (ADMA). This study is aimed at …