An updated review of the molecular mechanisms in drug hypersensitivity

CB Chen, R Abe, RY Pan, CW Wang… - Journal of …, 2018 - Wiley Online Library
Drug hypersensitivity may manifest ranging from milder skin reactions (eg, maculopapular
exanthema and urticaria) to severe systemic reactions, such as anaphylaxis, drug reactions …

Drugs and the skin: A concise review of cutaneous adverse drug reactions

BR Del Pozzo‐Magaña… - British Journal of Clinical …, 2024 - Wiley Online Library
Drug‐induced skin disease or cutaneous adverse drug reactions (CADRs) are terms that
encompass the clinical manifestations of the skin, mucosae and adnexa induced by a drug …

Metamizole (dipyrone) and the liver: a review of the literature

M Lutz - The Journal of Clinical Pharmacology, 2019 - Wiley Online Library
Metamizole, also known as dipyrone, was introduced to the market nearly a century ago.
Due to its excellent analgesic, antipyretic, and spasmolytic properties combined with its …

[HTML][HTML] Clinical features, outcomes and treatment in children with drug induced Stevens-Johnson syndrome and toxic epidermal necrolysis

L Lucia, C Silvia, B Paolo, B Roberto… - Acta Bio Medica …, 2019 - ncbi.nlm.nih.gov
Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN), which can be
considered a late-onset allergic reaction, can cause serious long-term sequelae. SJS/TEN …

In vitro assays in severe cutaneous adverse drug reactions: are they still research tools or diagnostic tests already?

G Porebski - International Journal of Molecular Sciences, 2017 - mdpi.com
Severe cutaneous adverse drug reactions (SCARs) represent life-threatening medical
conditions and an appropriate causative diagnosis of these conditions is of the highest …

Severe cutaneous adverse reactions: the pharmacogenomics from research to clinical implementation

SC Su, SI Hung, WL Fan, RL Dao… - International Journal of …, 2016 - mdpi.com
Severe cutaneous adverse reactions (SCARs), previously thought to be idiosyncratic or
unpredictable, are a deadly form of adverse drug reactions with skin manifestations. Current …

Pathophysiology of drug hypersensitivity

AA Elzagallaai, MJ Rieder - British Journal of Clinical …, 2024 - Wiley Online Library
Drug hypersensitivity reactions (DHRs) are type B adverse drug reactions (ADRs)
traditionally defined as unpredictable, dose independent and not related to the drug …

Adverse drug reactions across the age continuum: epidemiology, diagnostic challenges, prevention, and treatments

M Rieder - The Journal of Clinical Pharmacology, 2018 - Wiley Online Library
Adverse drug reactions (ADRs) are common and important complications of drug therapy for
children. The risk for ADRs changes over childhood, as do the nature and types of ADRs …

Adverse drug reactions in children: pediatric pharmacy and drug safety

M Rieder - The journal of pediatric pharmacology and …, 2019 - meridian.allenpress.com
An underappreciated problem in child health is the risk for adverse drug reactions (ADRs).
While there is an impression that children are at a lower risk than adults for ADRs, in fact a …

Carba analogues of flupirtine and retigabine with improved oxidation resistance and reduced risk of quinoid metabolite formation

KW Wurm, FM Bartz, L Schulig, A Bodtke… - …, 2022 - Wiley Online Library
The KV7 potassium channel openers flupirtine and retigabine have been valuable options in
the therapy of pain and epilepsy. However, as a result of adverse reactions, both drugs are …