Post-translational modifications (PTMs) are central to the modulation of protein activity,
stability, subcellular localization, and interaction with partners. They greatly expand the …

PARP inhibitors (PARPi) cause synthetic lethality in BRCA-deficient tumors. Whether
specific vulnerabilities to PARPi exist beyond BRCA mutations and related defects in …

Abstract Poly (ADP-ribose) polymerase 1 (PARP1) is essential for the progression of several
types of cancers. However, whether and how PARP1 is stabilized to promote genomic …

Abstract Background and Aim: DOT1L regulates various genes involved in cancer onset and
progression by catalyzing H3K79 methylation, but how DOT1L activity itself is regulated is …

C-to-G base editors have been successfully constructed recently, but limited work has been
done on concurrent C-to-G and A-to-G base editing. In addition, there is also limited data on …

Mutual crosstalk among poly (ADP-ribose)(PAR), activated PAR polymerase 1 (PARP1)
metabolites, and DNA repair machinery has emerged as a key regulatory mechanism of the …

Ubiquitin widely modifies proteins, thereby regulating most cellular functions. The complexity
of ubiquitin signalling necessitates unbiased methods enabling global detection of dynamic …

Altered expression of the translation factor eIF3e is associated with breast cancer
occurrence. We have previously shown that eIF3e deficiency leads to an impaired DNA …

Abstract Poly (ADP‐ribose) polymerase 1 (PARP1) is a key molecular stress sensor and
response mediator implicated in multiple cellular functions in health and diseases. Despite …

The ubiquitin signaling pathway is crucial for the DNA damage response pathway. More
specifically, RNF168 is integral in regulating DNA repair proteins at damaged chromatin …