DNA methylation is of paramount importance for mammalian embryonic development. DNA
methylation has numerous functions: it is implicated in the repression of transposons and …

Long non-coding RNAs (lncRNAs) are a diverse class of RNAs that engage in numerous
biological processes across every branch of life. Although initially discovered as mRNA-like …

Genome-wide sequencing has led to the discovery of thousands of long non-coding RNA
(lncRNA) loci in the human genome, but evidence of functional significance has remained …

Genomic imprinting affects a subset of genes in mammals and results in a monoallelic,
parental-specific expression pattern. Most of these genes are located in clusters that are …

Maternally expressed gene 3 (MEG3) is an imprinted gene belonging to the imprinted DLK1–
MEG3 locus located at chromosome 14q32. 3 in humans. Its mouse ortholog, Meg3, also …

The emerging awareness of the contribution of epigenetic processes to genome function in
health and disease is underpinned by decades of research in model systems. In particular …

Polycomb proteins play essential roles in stem cell renewal and human disease. Recent
studies of HOX genes and X inactivation have provided evidence for RNA cofactors in …

DNA-binding transcriptional regulators interpret the genome's regulatory code by binding to
specific sequences to induce or repress gene expression. Comparative genomics has …

Normal mammalian development requires a maternal and paternal contribution, which is
attributed to imprinted genes, or genes that are expressed from a single parental allele …

The iodothyronine deiodinases initiate or terminate thyroid hormone action and therefore
are critical for the biological effects mediated by thyroid hormone. Over the years, research …