Therapeutic strategies targeting FOXO transcription factors
FOXO proteins are transcription factors that are involved in numerous physiological
processes and in various pathological conditions, including cardiovascular disease, cancer …
processes and in various pathological conditions, including cardiovascular disease, cancer …
FOXO transcription factors as therapeutic targets in human diseases
A Orea-Soufi, J Paik, J Bragança, TA Donlon… - Trends in …, 2022 - cell.com
Forkhead box (FOX) O proteins are transcription factors (TFs) with four members in
mammals designated FOXO1, FOXO3, FOXO4, and FOXO6. FOXO TFs play a pivotal role in …
mammals designated FOXO1, FOXO3, FOXO4, and FOXO6. FOXO TFs play a pivotal role in …
Genome-wide association analyses of risk tolerance and risky behaviors in over 1 million individuals identify hundreds of loci and shared genetic influences
Humans vary substantially in their willingness to take risks. In a combined sample of over 1
million individuals, we conducted genome-wide association studies (GWAS) of general risk …
million individuals, we conducted genome-wide association studies (GWAS) of general risk …
Long live FOXO: unraveling the role of FOXO proteins in aging and longevity
Aging constitutes the key risk factor for age‐related diseases such as cancer and
cardiovascular and neurodegenerative disorders. Human longevity and healthy aging are …
cardiovascular and neurodegenerative disorders. Human longevity and healthy aging are …
[HTML][HTML] FoxO integration of insulin signaling with glucose and lipid metabolism
S Lee, HH Dong - The Journal of endocrinology, 2017 - ncbi.nlm.nih.gov
The forkhead box O family consists of FoxO1, FoxO3, FoxO4 and FoxO6 proteins in
mammals. Expressed ubiquitously in the body, the four FoxO isoforms share in common the …
mammals. Expressed ubiquitously in the body, the four FoxO isoforms share in common the …
Role of FoxO transcription factors in aging and age-related metabolic and neurodegenerative diseases
S Du, H Zheng - Cell & bioscience, 2021 - Springer
Aging happens to all of us as we live. Thanks to the improved living standard and discovery
of life-saving medicines, our life expectancy has increased substantially across the world in …
of life-saving medicines, our life expectancy has increased substantially across the world in …
Dendritic spines: the locus of structural and functional plasticity
C Sala, M Segal - Physiological reviews, 2014 - journals.physiology.org
The introduction of high-resolution time lapse imaging and molecular biological tools has
changed dramatically the rate of progress towards the understanding of the complex …
changed dramatically the rate of progress towards the understanding of the complex …
A genetic link between risk for Alzheimer's disease and severe COVID-19 outcomes via the OAS1 gene
Recently, we reported oligoadenylate synthetase 1 (OAS1) contributed to the risk of
Alzheimer's disease, by its enrichment in transcriptional networks expressed by microglia …
Alzheimer's disease, by its enrichment in transcriptional networks expressed by microglia …
FOXO transcription factors: their clinical significance and regulation
Y Wang, Y Zhou, DT Graves - BioMed research international, 2014 - Wiley Online Library
Members of the class O of forkhead box transcription factors (FOXO) have important roles in
metabolism, cellular proliferation, stress resistance, and apoptosis. The activity of FOXOs is …
metabolism, cellular proliferation, stress resistance, and apoptosis. The activity of FOXOs is …
FoxO transcription factors: their roles in the maintenance of skeletal muscle homeostasis
AMJ Sanchez, RB Candau, H Bernardi - Cellular and Molecular Life …, 2014 - Springer
Forkhead box class O family member proteins (FoxOs) are highly conserved transcription
factors with important roles in cellular homeostasis. The four FoxO members in humans …
factors with important roles in cellular homeostasis. The four FoxO members in humans …