Phase-shift nanodroplets as an emerging sonoresponsive nanomaterial for imaging and drug delivery applications

W Zhang, Y Shi, S Abd Shukor, A Vijayakumaran… - Nanoscale, 2022 - pubs.rsc.org
Nanodroplets–emerging phase-changing sonoresponsive materials–have attracted
substantial attention in biomedical applications for both tumour imaging and therapeutic …

Liquid Perfluorocarbons as Contrast Agents for Ultrasonography and 19F-MRI

R Díaz-López, N Tsapis, E Fattal - Pharmaceutical research, 2010 - Springer
Perfluorocarbons (PFCs) are fluorinated compounds that have been used for many years in
clinics mainly as gas/oxygen carriers and for liquid ventilation. Besides this main application …

Formulation and acoustic studies of a new phase-shift agent for diagnostic and therapeutic ultrasound

PS Sheeran, S Luois, PA Dayton, TO Matsunaga - Langmuir, 2011 - ACS Publications
Recent efforts in the area of acoustic droplet vaporization with the objective of designing
extravascular ultrasound contrast agents has led to the development of stabilized, lipid …

Characterization of submicron phase-change perfluorocarbon droplets for extravascular ultrasound imaging of cancer

R Williams, C Wright, E Cherin, N Reznik, M Lee… - Ultrasound in medicine …, 2013 - Elsevier
Because many tumors possess blood vessels permeable to particles with diameters of 200
nm, it is possible that submicron perfluorocarbon droplets could constitute a novel …

Investigation of vaporized submicron perfluorocarbon droplets as an ultrasound contrast agent

N Reznik, R Williams, PN Burns - Ultrasound in medicine & biology, 2011 - Elsevier
Acoustically activated submicron droplets of liquid perfluorocarbon are investigated as a
new class of ultrasound contrast agent. In the liquid state, intravascular droplets can …

A comparison of sonothrombolysis in aged clots between low-boiling-point phase-change nanodroplets and microbubbles of the same composition

J Kim, RM DeRuiter, L Goel, Z Xu, X Jiang… - Ultrasound in medicine & …, 2020 - Elsevier
We present enhanced cavitation erosion of blood clots exposed to low-boiling-point (− 2° C)
perfluorocarbon phase-change nanodroplets and pulsed ultrasound, as well as …

Materials chemistry of nanoultrasonic biomedicine

H Tang, Y Zheng, Y Chen - Advanced Materials, 2017 - Wiley Online Library
As a special cross‐disciplinary research frontier, nanoultrasonic biomedicine refers to the
design and synthesis of nanomaterials to solve some critical issues of ultrasound (US) …

Methods of generating submicrometer phase-shift perfluorocarbon droplets for applications in medical ultrasonography

PS Sheeran, N Matsuura, MA Borden… - IEEE transactions on …, 2016 - ieeexplore.ieee.org
Continued advances in the field of ultrasound and ultrasound contrast agents have created
new approaches to imaging and medical intervention. Phase-shift perfluorocarbon droplets …

Acoustic droplet vaporization in biology and medicine

CY Lin, WG Pitt - BioMed research international, 2013 - Wiley Online Library
This paper reviews the literature regarding the use of acoustic droplet vaporization (ADV) in
clinical applications of imaging, embolic therapy, and therapeutic delivery. ADV is a physical …

In vitro characterization of perfluorocarbon droplets for focused ultrasound therapy

KC Schad, K Hynynen - Physics in Medicine & Biology, 2010 - iopscience.iop.org
Focused ultrasound therapy can be enhanced with microbubbles by thermal and cavitation
effects. However, localization of treatment is difficult as bioeffects can occur outside of the …