SspABCD–SspE is a phosphorothioation-sensing bacterial defence system with broad anti-phage activities
X Xiong, G Wu, Y Wei, L Liu, Y Zhang, R Su… - Nature …, 2020 - nature.com
Bacteria have evolved diverse mechanisms to fend off predation by bacteriophages. We
previously identified the Dnd system, which uses DndABCDE to insert sulfur into the DNA …
previously identified the Dnd system, which uses DndABCDE to insert sulfur into the DNA …
Functional and molecular insights into the role of Sae2 C-terminus in the activation of MRX endonuclease
CV Colombo, E Casari, M Gnugnoli… - Nucleic Acids …, 2024 - academic.oup.com
The yeast Sae2 protein, known as CtIP in mammals, once phosphorylated at Ser267,
stimulates the endonuclease activity of the Mre11-Rad50-Xrs2 (MRX) complex to cleave …
stimulates the endonuclease activity of the Mre11-Rad50-Xrs2 (MRX) complex to cleave …
[HTML][HTML] Exo1 cooperates with Tel1/ATM in promoting recombination events at DNA replication forks
M Galli, C Frigerio, CV Colombo, E Casari… - Iscience, 2024 - cell.com
Tel1/ataxia telangiectasia mutated (ATM) kinase plays multiple functions in response to DNA
damage, promoting checkpoint-mediated cell-cycle arrest and repair of broken DNA. In …
damage, promoting checkpoint-mediated cell-cycle arrest and repair of broken DNA. In …
Uncoupling Sae2 functions in downregulation of Tel1 and Rad53 signaling activities
CV Colombo, L Menin, R Ranieri, D Bonetti, M Clerici… - Genetics, 2019 - academic.oup.com
Abstract The Mre11-Rad50-Xrs2 (MRX) complex acts together with the Sae2 protein to
initiate resection of DNA double-strand breaks (DSBs) and to regulate a checkpoint …
initiate resection of DNA double-strand breaks (DSBs) and to regulate a checkpoint …