BDNF as a promising therapeutic agent in Parkinson's disease

E Palasz, A Wysocka, A Gasiorowska… - International journal of …, 2020 - mdpi.com
Brain-derived neurotrophic factor (BDNF) promotes neuroprotection and neuroregeneration.
In animal models of Parkinson's disease (PD), BDNF enhances the survival of dopaminergic …

Brain-derived neurotrophic factor in brain disorders: focus on neuroinflammation

B Lima Giacobbo, J Doorduin, HC Klein… - Molecular …, 2019 - Springer
Brain-derived neurotrophic factor (BDNF) is one of the most studied neurotrophins in the
healthy and diseased brain. As a result, there is a large body of evidence that associates …

Actions of brain-derived neurotrophin factor in the neurogenesis and neuronal function, and its involvement in the pathophysiology of brain diseases

T Numakawa, H Odaka, N Adachi - International journal of molecular …, 2018 - mdpi.com
It is well known that brain-derived neurotrophic factor, BDNF, has an important role in a
variety of neuronal aspects, such as differentiation, maturation, and synaptic function in the …

Neurotrophic factors in Alzheimer's and Parkinson's diseases: implications for pathogenesis and therapy

TB Sampaio, AS Savall, MEZ Gutierrez… - Neural regeneration …, 2017 - journals.lww.com
Neurotrophic factors comprise essential secreted proteins that have several functions in
neural and non-neural tissues, mediating the development, survival and maintenance of …

[PDF][PDF] Moderate-intensity interval training increases serum brain-derived neurotrophic factor level and decreases inflammation in Parkinson's disease patients

JA Zoladz, J Majerczak, E Zeligowska… - J Physiol …, 2014 - instituteofmotion.com
It has been demonstrated that physical training increases serum brain-derived neurotrophic
factor (BDNF) in healthy people. The aim of this study was to establish the effect of physical …

Dietary plant polyphenols as the potential drugs in neurodegenerative diseases: current evidence, advances, and opportunities

L Yan, MS Guo, Y Zhang, L Yu, JM Wu… - Oxidative Medicine …, 2022 - Wiley Online Library
Neurodegenerative diseases, including Alzheimer's disease (AD), Parkinson's disease (PD),
and Huntington's disease (HD), are characterized by the progressive degeneration of …

Molecular mechanisms of brain-derived neurotrophic factor in neuro-protection: recent developments

H Zhao, A Alam, CY San, S Eguchi, Q Chen, Q Lian… - Brain research, 2017 - Elsevier
Neuronal cell injury, as a consequence of acute or chronic neurological trauma, is a
significant cause of mortality around the world. On a molecular level, the condition is …

Intensive rehabilitation increases BDNF serum levels in parkinsonian patients: a randomized study

G Frazzitta, R Maestri, MF Ghilardi… - … and neural repair, 2014 - journals.sagepub.com
Background. Exercise may decrease the risk of Parkinson's disease (PD) in humans and
reduce PD symptoms in animal models. The beneficial effects have been linked to increased …

Neurotrophic factors for disease-modifying treatments of Parkinson's disease: gaps between basic science and clinical studies

P Chmielarz, M Saarma - Pharmacological Reports, 2020 - Springer
Background Neurotrophic factors are endogenous proteins promoting the survival of
different neural cells. Therefore, they elicited great interest as a possible treatment for …

Cognitive impairment and BDNF serum levels

J Siuda, M Patalong-Ogiewa, W Żmuda… - Neurologia i …, 2017 - journals.viamedica.pl
Results AD patients had significantly lower (p< 0.001) BDNF serum levels compared to MCI,
CN and ND controls. Age and education had significant influence on BDNF serum levels …