The accumulation of amyloid-β (Aβ) aggregates is found in the brains of Alzheimer's disease
patients. Thus, numerous efforts have been made to develop chemical reagents capable of …

Amyloid-β (Aβ) oligomers are a cause of neurodegeneration in Alzheimer's disease (AD).
These soluble aggregates of the Aβ peptide have proven difficult to study due to their …

Structural properties and aggregation tendency can be significantly influenced by histidine
behaviors (histidine on N δ-H state is defined as δ, likewise, N ε-H: ε and both N δ-H and N ε …

The histidine behavior plays a crucial role in the structural and aggregation properties of
protein folding and misfolding. Understanding the histidine behavior at the edge of the …

In this study, we compared the effects of two well-known natural compounds on the early
step of the fibrillation process of amyloid-β (1–40), responsible for the formation of plaques …

The self-assembly of amyloid-β (Aβ) peptides into senile plaques in the brain is a hallmark of
Alzheimer's disease (AD) pathology. Mutation and histidine tautomerism are considered …

Heavy evidence has confirmed that Aβ42 oligomers are the most neurotoxic aggregates and
play a critical role in the occurrence and development of Alzheimer's disease by causing …

Mutation is considered an important factor in the accumulation of amyloid-β (Aβ), which is a
hallmark of Alzheimer's disease (AD). A2V Aβ40 shows a higher aggregation tendency; …

The accumulation of ΔK280 tau mutant resulting in neurotoxic oligomeric aggregates is an
important but yet mysterious procedure in Alzheimer's disease (AD) development. Recently …

Many studies have focused on histidine behaviors in misfolding diseases. However,
histidine behaviors on mature fibrils are still unknown. In the current study, we investigated …