Chronologic age is the dominant risk factor for coronary artery disease but the features of
aging promoting coronary artery disease are poorly understood. Advances in human …

Clonal hematopoiesis (CH) is an age-related process whereby hematopoietic stem and
progenitor cells (HSPCs) acquire mutations that lead to a proliferative advantage and clonal …

Background Clonal hematopoiesis of indeterminate potential (CHIP)—the age-related clonal
expansion of blood stem cells with leukemia-associated mutations—is a novel …

Background Clonal hematopoiesis of indeterminate potential (CHIP) is common in elderly
individuals and is associated with an increased risk of both hematologic malignancies and …

Clonal hematopoiesis of indeterminate potential (CHIP) is a common bone marrow
abnormality induced by age‐related DNA mutations, which give rise to proinflammatory …

Recent clinical and research efforts in cardiogenic shock (CS) have largely focussed on the
restoration of the low cardiac output state that is the conditio sine qua non of the clinical …

With advances in sequencing, individuals with clonal hematopoiesis of indeterminate
potential (CHIP) are increasingly being identified, making it essential to understand its …

Circulatory shock is defined syndromically as hypotension associated with tissue
hypoperfusion and often subcategorized according to hemodynamic profile (eg, distributive …

BACKGROUND: Clonal hematopoiesis of indeterminate potential (CHIP) occurs due to
acquired mutations in bone marrow progenitor cells. CHIP confers a 2-fold risk of …

Somatic mutations in the TET2 gene occur more frequently with age, imparting an intrinsic
hematopoietic stem cells (HSCs) advantage and contributing to a phenomenon termed …