The obesity and diabetes pandemics have made it an urgent necessity to define the central
nervous system (CNS) pathways controlling body weight, energy expenditure, and fuel …

The role of nutrition and balanced metabolism in normal growth, development, and health
maintenance is well known. Patients affected with either acute or chronic diseases often …

Insulin action in the central nervous system regulates energy homeostasis and glucose
metabolism. To define the insulin-responsive neurons that mediate these effects, we …

Abstract Steroidogenic factor 1 (SF-1)-expressing neurons of the ventromedial
hypothalamus (VMH) control energy homeostasis, but the role of insulin action in these cells …

Protein tyrosine phosphatase 1B (PTP1B) and SH2 domain–containing protein tyrosine
phosphatase–2 (SHP2) have been shown in mice to regulate metabolism via the central …

Insulin-and leptin-stimulated phosphatidylinositol-3 kinase (PI3K) activation has been
demonstrated to play a critical role in central control of energy homeostasis. To delineate the …

Summary Cardiotrophin-1 (CT-1) is a member of the gp130 family of cytokines. We observed
that ct-1−/− mice develop mature-onset obesity, insulin resistance, and …

Body weight is tightly controlled in a species-specific range from insects to vertebrates and
organisms have developed a complex regulatory network in order to avoid either excessive …

Obesity and its related cluster of pathophysiologic conditions including insulin resistance,
glucose intolerance, dyslipidemia, and hypertension are recognized as growing threats to …

It is well known that obesity is responsible, at least in part, for the increased incidence of
chronic diseases such as type 2 diabetes, cardiovascular disease and certain types of …