There is a high incidence of chromosomal abnormalities in early human embryos, whether
they are generated by natural conception or by assisted reproductive technologies (ART) …

BACKGROUND Transfer of more than a single embryo in an IVF cycle comes with the finite
possibility of a multiple gestation. Even a twin pregnancy confers significant risk to both …

Preimplantation genetic testing for aneuploidy (PGT-A) is widely used in IVF and aims to
improve outcomes by avoiding aneuploid embryo transfers. Chromosomal mosaicism is …

De novo copy-number variants (CNVs) can cause neuropsychiatric disease, but the degree
to which they occur somatically, and during development, is unknown. Single-cell whole …

STUDY QUESTION Can next-generation sequencing (NGS) techniques be used reliably for
comprehensive aneuploidy screening of human embryos from patients undergoing IVF …

Objective To validate a next-generation sequencing (NGS)–based method for 24-
chromosome aneuploidy screening and to investigate its applicability to preimplantation …

Background The majority of human embryos created using in vitro fertilisation (IVF)
techniques are aneuploid. Comprehensive chromosome screening methods, applicable to …

Human reproduction is remarkably inefficient; nearly 70% of human conceptions do not
survive to live birth. Spontaneous fetal aneuploidy is the most common cause for …

STUDY QUESTION To what extent does a trophectoderm (TE) biopsy reliably reflect the
chromosomal constitution of the inner cell mass (ICM) in human blastocysts? SUMMARY …

BACKGROUND Embryos that are able to form blastocysts have succeeded in activating their
genome and differentiating into two cell types—an external layer of trophectoderm cells …