Organoids are three-dimensional (3D) miniature structures cultured in vitro produced from
either human pluripotent stem cells (hPSCs) or adult stem cells (AdSCs) derived from …

Organoids are in vitro miniaturized and simplified model systems of organs that have gained
enormous interest for modelling tissue development and disease, and for personalized …

Predicting the effects of drugs before human clinical trials is at the heart of drug screening
and discovery processes. The cost of drug discovery is steadily increasing owing to the …

Inherited retinal diseases (IRDs) are a clinically complex and heterogenous group of visual
impairment phenotypes caused by pathogenic variants in at least 277 nuclear and …

Modeling the processes of neuronal progenitor proliferation and differentiation to produce
mature cortical neuron subtypes is essential for the study of human brain development and …

Organoids are 3D in vitro culture systems derived from self-organizing stem cells. They can
recapitulate the in vivo architecture, functionality, and genetic signature of original tissues …

To study the development of the human retina, we use single-cell RNA sequencing (RNA-
seq) at key fetal stages and follow the development of the major cell types as well as …

Recent advances in generating three-dimensional (3D) organoid systems from stem cells
offer new possibilities for disease modeling and drug screening because organoids can …

The advent of human induced pluripotent stem cells (iPSCs) presents unprecedented
opportunities to model human diseases. Differentiated cells derived from iPSCs in two …

Retinoblastoma is a childhood cancer of the developing retina that initiates with biallelic
inactivation of the RB1 gene. Children with germline mutations in RB1 have a high …