Ageing organisms accumulate senescent cells that are thought to contribute to body
dysfunction. Telomere shortening and damage are recognized causes of cellular …

Most older individuals develop inflammageing, a condition characterized by elevated levels
of blood inflammatory markers that carries high susceptibility to chronic morbidity, disability …

Abstract SIRT1 (Sir2) is an NAD+-dependent deacetylase that plays critical roles in a broad
range of biological events, including metabolism, the immune response and ageing …

Aging is a prominent risk factor for cardiovascular diseases, which is the leading cause of
death around the world. Recently, cellular senescence has received potential attention as a …

Aging leads to increased cellular senescence and is associated with decreased potency of
tissue‐specific stem/progenitor cells. Here, we have done an extensive analysis of cardiac …

The average lifespan of humans is increasing, and with it the percentage of people entering
the 65 and older age group is growing rapidly and will continue to do so in the next 20 years …

Cell senescence is an important tumour suppressor mechanism and driver of ageing. Both
functions are dependent on the development of the senescent phenotype, which involves an …

Aging is a biological feature that is characterized by gradual degeneration of function in
cells, tissues, organs, or an intact organism due to the accumulation of environmental factors …

Human aging is characterized by both physical and physiological frailty that profoundly
affects the immune system. In this context aging is associated with declines in adaptive and …

Aging is the main risk factor for Alzheimer's disease (AD); however, the aspects of the aging
process that predispose the brain to the development of AD are largely unknown. Astrocytes …