The recognition of invading pathogens and endogenous molecules from damaged tissues
by toll-like receptors (TLRs) triggers protective self-defense mechanisms. However …

Chronic graft-versus-host disease (GVHD) is the leading cause of late, nonrelapse mortality
and disability in allogeneic hematopoietic cell transplantation recipients and a major …

Graphene oxide (GO) is increasingly used in biomedical applications because it possesses
not only the unique properties of graphene including large surface area and flexibility but …

Allogeneic haematopoietic stem cell transplantation is used to treat a variety of disorders,
but its efficacy is limited by the occurrence of graft-versus-host disease (GVHD). The past …

Toll-like receptors (TLRs) are components of the innate immune system that respond to
exogenous infectious ligands (pathogen-associated molecular patterns, PAMPs) and …

Toll-like receptors (TLRs) sense invading microbial pathogens and play crucial roles in the
activation of innate and adaptive immunity. However, excessive TLR activation can disrupt …

The continuous emergence of infectious pathogens along with antimicrobial resistance
creates a need for an alternative approach to treat infectious diseases. Targeting host factor …

Cardiovascular disease is a leading cause of death worldwide and is associated with
systemic inflammation. In depth study of the cell-specific signaling mechanisms mediating …

Inflammation is set off when innate immune cells detect infection or tissue injury. Tight
control of the severity, duration, and location of inflammation is an absolute requirement for …

Myeloid differentiation primary response protein 88 (MyD88) is a ubiquitously expressed
cytoplasmic adaptor protein that plays a central role in the Toll-like receptor (TLR) and …