Neutrophils are the most abundant leukocyte population in the human circulatory system
and are rapidly recruited to sites of inflammation. Neutrophils play a multifaceted role in …

Chronic pain has been widely recognized as a major public health problem that impacts
multiple aspects of patient quality of life. Unfortunately, chronic pain is often resistant to …

It was realized in the 1990s that some membrane proteins such as TNFα, both TNF
receptors, ligands of the EGF-R and the Interleukin-6 receptor are proteolytically cleaved …

Chronic neuropathic pain constitutes a serious public health problem, but the disease
mechanisms are only partially understood. The involvement of different brain regions like the …

Oral cancer pain remains a significant public health concern. Despite the development of
improved treatments, pain continues to be a debilitating clinical feature of the disease …

Neurotoxicity is a common side effect of chemotherapeutics that often leads to the
development of chemotherapy-induced peripheral neuropathy (CIPN). The peptide …

Preclinical research using different rodent model systems has largely contributed to the
scientific progress in the pain field, however, it suffers from interspecies differences, limited …

The auxiliary α2δ subunits of voltage-gated calcium (CaV) channels are key to augmenting
expression and function of CaV1 and CaV2 channels, and are also important drug targets in …

Neuropathic pain (NP) is an ineffectively treated, debilitating chronic pain disorder that is
associated with maladaptive changes in the central nervous system, particularly in the spinal …

The pathogenesis of painful diabetic neuropathy (PDN) is complicated and remains not fully
understood. A disintegrin and metalloprotease 17 (ADAM17) is an enzyme that is …