Transcription of eukaryotic protein-coding genes commences with the assembly of a
conserved initiation complex, which consists of RNA polymerase II (Pol II) and the general …

In eukaryotes, the core promoter serves as a platform for the assembly of transcription
preinitiation complex (PIC) that includes TFIIA, TFIIB, TFIID, TFIIE, TFIIF, TFIIH, and RNA …

Here we review recent advances in understanding the regulation of mRNA synthesis in
Saccharomyces cerevisiae. Many fundamental gene regulatory mechanisms have been …

The general transcription factor IID (TFIID) plays a central role in the initiation of RNA
polymerase II (Pol II)-dependent transcription by nucleating pre-initiation complex (PIC) …

Advances in structure determination of the bacterial and eukaryotic transcription machinery
have led to a marked increase in the understanding of the mechanism of transcription …

Previous studies suggested that expression of most yeast mRNAs is dominated by either
transcription factor TFIID or SAGA. We re-examined the role of TFIID by rapid depletion of S …

INTRODUCTION In eukaryotes, transcription initiation starts with the assembly of the
transcription preinitiation complex (PIC) onto promoter DNA. The PIC comprises the general …

Eukaryotic gene transcription requires the assembly at the promoter of a large preinitiation
complex (PIC) that includes RNA polymerase II (Pol II) and the general transcription factors …

The initiation of gene transcription by RNA polymerase II is regulated by a plethora of
proteins in human cells. The first general transcription factor to bind gene promoters is …

In vitro experiments led to a simple model in which basal transcription factors sequentially
assembled with RNA Polymerase II to generate a preinitiation complex (PIC). Emerging …