Amyloid-β and tau complexity—towards improved biomarkers and targeted therapies

JC Polanco, C Li, LG Bodea… - Nature Reviews …, 2018 - nature.com
Most neurodegenerative diseases are proteinopathies, which are characterized by the
aggregation of misfolded proteins. Although many proteins have an intrinsic propensity to …

Amyloid beta: multiple mechanisms of toxicity and only some protective effects?

P Carrillo-Mora, R Luna… - Oxidative medicine and …, 2014 - Wiley Online Library
Amyloid beta (Aβ) is a peptide of 39–43 amino acids found in large amounts and forming
deposits in the brain tissue of patients with Alzheimer's disease (AD). For this reason, it has …

Peptide-lipid interactions: experiments and applications

S Galdiero, A Falanga, M Cantisani, M Vitiello… - International journal of …, 2013 - mdpi.com
The interactions between peptides and lipids are of fundamental importance in the
functioning of numerous membrane-mediated cellular processes including antimicrobial …

The spin label amino acid TOAC and its uses in studies of peptides: chemical, physicochemical, spectroscopic, and conformational aspects

S Schreier, JC Bozelli, N Marín, RFF Vieira… - Biophysical …, 2012 - Springer
We review work on the paramagnetic amino acid 2, 2, 6, 6-tetramethyl-N-oxyl-4-amino-4-
carboxylic acid, TOAC, and its applications in studies of peptides and peptide synthesis …

Putative Pore Structures of Amyloid β 25–35 in Lipid Bilayers

A Dutta, A Sepehri, T Lazaridis - Biochemistry, 2023 - ACS Publications
The amyloid β peptide aggregates to form extracellular plaques in the brains of Alzheimer's
disease patients. Certain of its fragments have been found to have similar properties to …

EPR study of the interactions between dendrimers and peptides involved in Alzheimer's and prion diseases

B Klajnert, M Cangiotti, S Calici… - Macromolecular …, 2007 - Wiley Online Library
Spin‐probe and spin‐label techniques were used to study the interactions of the Aβ 1–28
peptide involved in Alzheimer disease and the PrP 106–126 peptide suspected to be …

Altered Ca2+ dependence of synaptosomal plasma membrane Ca2+‐ATPase in human brain affected by Alzheimer's disease

M Berrocal, D Marcos, MR Sepúlveda… - The FASEB …, 2009 - Wiley Online Library
ABSTRACT High‐affinity Ca2+ transport ATPases play a crucial role in controlling cytosolic
Ca2+. The amyloid β‐peptide (Aβ) is a neurotoxic agent found in affected neurons in …

Investigating the Neuroprotective Effects of Turmeric Extract: Structural Interactions of β-Amyloid Peptide with Single Curcuminoids

R Randino, M Grimaldi, M Persico, A De Santis… - Scientific reports, 2016 - nature.com
A broad biophysical analysis was performed to investigate the molecular basis of the
neuroprotective action of Curcuma longa extracts in Alzheimer's disease. By combining …

[HTML][HTML] Interaction between Alzheimer's Aβ (25–35) peptide and phospholipid bilayers: The role of cholesterol

G D'Errico, G Vitiello, O Ortona, A Tedeschi… - … et Biophysica Acta (BBA …, 2008 - Elsevier
There is mounting evidence that the lipid matrix of neuronal cell membranes plays an
important role in the accumulation of β-amyloid peptides into senile plaques, one of the …

β-Amyloid-acetylcholine molecular interaction: new role of cholinergic mediators in anti-Alzheimer therapy?

M Grimaldi, SD Marino, F Florenzano… - Future medicinal …, 2016 - Taylor & Francis
Background: For long time Alzheimer's disease has been attributed to a cholinergic deficit.
More recently, it has been considered dependent on the accumulation of the amyloid beta …